Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects

• Published in: Regulatory peptides Vol. 114; no. 2; pp. 115 - 121
• Main Authors: Vilsbøll, Tina, Krarup, Thure, Madsbad, Sten, Holst, Jens J.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 15.07.2003; Amsterdam Elsevier
• Subjects: Adult; Biological and medical sciences; Blood Glucose - metabolism; C-Peptide - blood; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Gastric Inhibitory Polypeptide - administration & dosage; Gastric Inhibitory Polypeptide - physiology; Gastrointestinal hormones; GIP receptors; Glucagon - administration & dosage; Glucagon - blood; Glucagon - physiology; Glucagon-Like Peptide 1; Glucagon-like peptide-1 (GLP-1); Glucose - administration & dosage; Glucose-dependent insulinotropic polypeptide (GIP); Humans; Incretin hormones; Insulin - blood; Insulin - metabolism; Insulin Secretion; Male; Peptide Fragments - administration & dosage; Peptide Fragments - physiology; Postprandial Period; Protein Precursors - administration & dosage; Protein Precursors - physiology; Reference Values; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: digestive system; Glucagon-like peptide-1 (GLP-1); GLP-1; DPP-IV; Glucose-dependent insulinotropic polypeptide (GIP); Incretin hormones; FPG; GIP receptors; Insulin secretion; GIP; AUC; Human; Pancreatic hormone; Healthy subject; Postprandial; Meal; Glucose; Insulin; Glucagon like peptide 1; Gastrointestinal hormone; Polypeptide; Gastric inhibitory peptide

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are both incretin hormones regulating postprandial insulin secretion. Their relative importance in this respect under normal physiological conditions is unclear, however, and the aim of the present investigation w...