Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy

• Published in: Kidney international Vol. 78; no. 3; pp. 287 - 295
• Main Authors: Penfold, Sally A., Coughlan, Melinda T., Patel, Sheila K., Srivastava, Piyush M., Sourris, Karly C., Steer, David, Webster, Diane E., Thomas, Merlin C., MacIsaac, Richard J., Jerums, George, Burrell, Louise M., Cooper, Mark E., Forbes, Josephine M.
• Format: Journal Article
• Language: English
• Published: Basingstoke Elsevier Inc 01.08.2010; Nature Publishing Group; Elsevier Limited
• Subjects: advanced glycation end product; Aged; Antibodies, Neutralizing - metabolism; Associated diseases and complications; Biological and medical sciences; Case-Control Studies; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - blood; Diabetic Nephropathies - metabolism; diabetic nephropathy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzyme-Linked Immunosorbent Assay; Female; high-mobility group box 1; HMGB1 Protein - analysis; HMGB1 Protein - metabolism; Humans; Kidneys; Ligands; Lysine - analogs & derivatives; Lysine - analysis; Lysine - metabolism; Male; Medical sciences; Middle Aged; Molecular Weight; Nephrology. Urinary tract diseases; Protein Kinase C-alpha - metabolism; RAGE; Receptor for Advanced Glycation End Products; Receptors, Immunologic - metabolism; Transcription, Genetic; Urinary system involvement in other diseases. Miscellaneous; advanced glycation end product; high-mobility group box 1; RAGE; diabetic nephropathy; Endocrinopathy; Kidney disease; Nephrology; Urinary system disease; Ligand; Diabetes mellitus; Mobility; Urology; Concomitant disease; Advanced glycation end products; High molecular weight; Receptor for advanced glycation endproducts; Development; Diabetic nephropathy

The accumulation of advanced glycation end products is thought to be a key factor in the initiation and progression of diabetic nephropathy. Here we determined whether the size of the ligands for the receptor for advanced glycation end products (RAGEs) that were present in the serum of patients with...