Synthesis, structure and in vitro antibacterial activities of new hybrid disinfectants quaternary ammonium compounds: Pyridinium and quinolinium stilbene benzenesulfonates

• Published in: European journal of medicinal chemistry Vol. 45; no. 9; pp. 4199 - 4208
• Main Authors: Chanawanno, Kullapa, Chantrapromma, Suchada, Anantapong, Theerasak, Kanjana-Opas, Akkharawit, Fun, Hoong-Kun
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 01.09.2010; Elsevier
• Subjects: Antibacterial; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria - drug effects; Benzenesulfonates - chemical synthesis; Benzenesulfonates - chemistry; Benzenesulfonates - pharmacology; Biological and medical sciences; Chemistry, Medicinal; Crystallography, X-Ray; Disinfectants; Disinfectants - chemical synthesis; Disinfectants - chemistry; Disinfectants - pharmacology; Life Sciences & Biomedicine; Medical sciences; Microbial Sensitivity Tests; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Pyridinium; Pyridinium Compounds - chemistry; Quaternary ammonium compounds (QACs); Quaternary Ammonium Compounds - chemical synthesis; Quaternary Ammonium Compounds - chemistry; Quaternary Ammonium Compounds - pharmacology; Quinolinium; Quinolinium Compounds - chemistry; Science & Technology; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stilbene; Antibacterial; Disinfectants; Quinolinium; Quaternary ammonium compounds (QACs); Pyridinium; Stilbene; OUTER-MEMBRANE; ANTIMICROBIAL ACTIVITIES; RESISTANCE; BENZALKONIUM CHLORIDE; Organic cation; Molecular structure; X ray diffraction; In vitro; Biological activity; Stilbene derivatives; Sulfonate; Quaternary ammonium compound; Pyridinium compounds; Antibacterial agent; Disinfecting agent; Chemical synthesis; Crystalline structure

The series of pyridinium ( 1–10) and quinolinium ( 11–20) stilbene benzenesulfonates have been synthesized and their structures were investigated by UV–vis, FT-IR and 1H NMR spectroscopy. In addition, compound 5 was also determined by single crystal X-ray diffraction technique. The antibacterial act...