Surfactant proteins SP-A and SP-D: Structure, function and receptors

• Published in: Molecular Immunology Vol. 43; no. 9; pp. 1293 - 1315
• Main Authors: Kishore, Uday, Greenhough, Trevor J., Waters, Patrick, Shrive, Annette K., Ghai, Rohit, Kamran, Mohammed F., Bernal, Andrés López, Reid, Kenneth B.M., Madan, Taruna, Chakraborty, Trinad
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2006
• Subjects: Allergens; Allergy; Amino Acid Sequence; Amniotic Fluid - physiology; Animals; Bacteria - pathogenicity; Crystal structure; Crystallography, X-Ray; Female; Fungi - pathogenicity; Humans; Immunity; Infection; Lung; Lung - immunology; Lung - microbiology; Lung - physiology; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Pregnancy; Pulmonary Surfactant-Associated Protein A - chemistry; Pulmonary Surfactant-Associated Protein A - genetics; Pulmonary Surfactant-Associated Protein A - immunology; Pulmonary Surfactant-Associated Protein A - physiology; Pulmonary Surfactant-Associated Protein D - chemistry; Pulmonary Surfactant-Associated Protein D - genetics; Pulmonary Surfactant-Associated Protein D - immunology; Pulmonary Surfactant-Associated Protein D - physiology; Receptors, Cell Surface - chemistry; Receptors, Cell Surface - physiology; Receptors, Immunologic - chemistry; Receptors, Immunologic - physiology; Sequence Homology, Amino Acid; Surfactant; Viruses - pathogenicity; Yeasts - pathogenicity; Allergy; CRT; A. fumigatus; Lung; MHC; ABPA; Surfactant; Immunity; LPS; GM-CSF; RT-PCR; SP; DPPC; Crystal structure; rhSP-D; rrSP-A; BALF; PBMC; ER; ET; PMN; Infection; PC; APC; CRD; RSV; PI; IPA; PAP; DC

Surfactant proteins, SP-A and SP-D, are collagen-containing C-type (calcium dependent) lectins called collectins, which contribute significantly to surfactant homeostasis and pulmonary immunity. These highly versatile innate immune molecules are involved in a range of immune functions including vira...