Immune Modulation of the T Cell Response in Asthma through Wnt10b

• Published in: American journal of respiratory cell and molecular biology Vol. 54; no. 4; pp. 584 - 593
• Main Authors: Trischler, Jordis, Shiomi, Takayuki, Turner, Damian L, Sklepkiewicz, Piotr L, Goldklang, Monica P, Tanaka, Kenji F, Xu, Ming, Farber, Donna L, D'Armiento, Jeanine M
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.04.2016
• Subjects: Allergies; Animals; Antigens; Asthma; Asthma - immunology; Bronchoalveolar Lavage Fluid; Cell Polarity; Dermatophagoides pteronyssinus; Disease; Disease Models, Animal; Laboratories; Ligands; Lung - immunology; Lungs; Lymphocytes; Mice; Mice, Knockout; Original Research; Pathogenesis; Rodents; Spleen - immunology; Spleen - pathology; Stem cells; Studies; T cell receptors; T-Lymphocytes - immunology; Transcription factors; Wnt Proteins - genetics; Wnt Proteins - physiology; T helper type 2; allergy; asthma; Wnt pathway; Wnt10b

Asthma is a chronic inflammatory disease, which is characterized by activation of CD4(+) T helper 2 cells orchestrating an allergic airway response. Whereas the role of Wnt family members in regulating T cell maintenance and maturation is established, their contribution to T cell activation in aller...