E2F1/SNHG7/miR-186-5p/MMP2 axis modulates the proliferation and migration of vascular endothelial cell in atherosclerosis

• Published in: Life sciences (1973) Vol. 257; p. 118013
• Main Authors: Zhang, Shengjie, Zhu, Xiaotong, Li, Guangping
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 15.09.2020; Elsevier BV
• Subjects: 3' Untranslated regions; Arteriosclerosis; Atherosclerosis; Cell migration; Cell proliferation; Cholecystokinin; Chromatin; chromatin immunoprecipitation; Endothelial cells; Gelatinase A; Immunoprecipitation; lncRNA; Low density lipoprotein; luciferase; MMP2; Molecular interactions; promoter regions; RNA; therapeutics; transcription factors; Umbilical vein; Western blotting; Wound healing; lncRNA; MMP2; Endothelial cells; Atherosclerosis

Emerging literature illustrates critical roles of long noncoding RNAs (lncRNAs) in the progression of atherosclerosis. However, the biological functions and mechanism by which lncRNAs regulate the atherosclerosis remain unclear. Human umbilical vein endothelial cells (HUVECs) were treated with oxida...