Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A

• Published in: Oncogene Vol. 18; no. 4; pp. 925 - 934
• Main Authors: YEYATI, P. L, SHAKNOVICH, R, BOTERASHVILI, S, JIA LI, BALL, H. J, WAXMAN, S, NASON-BURCHENAL, K, DMITROVSKY, E, ZELENT, A, LICHT, J. D
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 28.01.1999
• Subjects: 3T3 Cells; Animals; Biological and medical sciences; Cell Cycle - genetics; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 17; Cyclin A - metabolism; Cyclin-Dependent Kinases - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Fundamental and applied biological sciences. Psychology; Genetic Vectors; Humans; Interphase - genetics; Kruppel-Like Transcription Factors; Leukemia, Promyelocytic, Acute - genetics; Leukemia, Promyelocytic, Acute - metabolism; Leukemia, Promyelocytic, Acute - pathology; Mice; Molecular and cellular biology; Neoplasm Proteins - metabolism; Oncogene Proteins, Fusion - physiology; Promyelocytic Leukemia Zinc Finger Protein; S Phase - genetics; Transcription Factors - genetics; Transcription Factors - physiology; Translocation, Genetic; Zinc Fingers - physiology; Chromosomal aberration; Human; Promyelocytic leukemia; Cell proliferation; Acute; Malignant hemopathy; Gene expression; Carcinogenesis; Cell line; Cyclin A; Cell cycle; Abnormal chromosome; Fusion protein; Hybrid gene; Chromosome translocation

The PLZF gene was identified by its fusion with the RARalpha locus in a therapy resistant form of acute promyelocytic leukemia (APL) associated with the t(11;17)(q23;q21) translocation. Here we describe PLZF as a negative regulator of cell cycle progression ultimately leading to growth suppression....