Assessment of the activity of the immune system in patients with inflammatory bowel diseases and asymptomatic COVID-19
Although the phenomenon of cytokine storm is well described in patients with severe COVID-19, little is known about the role of the immune system in asymptomatic patients, especially in the group with autoimmune diseases, such as inflammatory bowel disease (IBD). To assess the stimulation of the imm...
Saved in:
Published in | Przegląd gastroenterologiczny Vol. 19; no. 1; pp. 46 - 53 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Poland
Termedia Publishing House
01.01.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Although the phenomenon of cytokine storm is well described in patients with severe COVID-19, little is known about the role of the immune system in asymptomatic patients, especially in the group with autoimmune diseases, such as inflammatory bowel disease (IBD).
To assess the stimulation of the immune system expressed through the production of cytokines in IBD patients with asymptomatic COVID-19.
This is a multi-centre, prospective study in which the concentration of many cytokines (IL-1a, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL- 15, IL-17, IL-23, IFN-γ, TNF-α, TNF-β) was assessed in patients with IBD and asymptomatic SARS-CoV-2 infection diagnosed by serological tests.
In the group of patients with a recent SARS-CoV-2 infection, defined as positive antibodies in the IgA + IgM class, a higher percentage of patients with the presence of interleukin (IL) 2 (IL-2) was found. No association with other cytokines or effects of IBD activity or treatment was found. However, the effect of the applied treatment on the concentration of some cytokines was found: a negative association of infliximab, vedolizumab, and prednisone with IL-2, a positive correlation of steroids, thiopurines with IL-10, and in the case of tumor necrosis factor-α (TNF-α), negative with infliximab, and positive with vedolizumab.
The increased concentration of IL-2 may result from its regulatory role in inhibiting excessive activation of the immune system; however, considering the studies of patients with severe COVID-19, its role in the initial phase of SARS-CoV-2 infection requires further research. |
---|---|
AbstractList | Although the phenomenon of cytokine storm is well described in patients with severe COVID-19, little is known about the role of the immune system in asymptomatic patients, especially in the group with autoimmune diseases, such as inflammatory bowel disease (IBD).
To assess the stimulation of the immune system expressed through the production of cytokines in IBD patients with asymptomatic COVID-19.
This is a multi-centre, prospective study in which the concentration of many cytokines (IL-1a, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL- 15, IL-17, IL-23, IFN-γ, TNF-α, TNF-β) was assessed in patients with IBD and asymptomatic SARS-CoV-2 infection diagnosed by serological tests.
In the group of patients with a recent SARS-CoV-2 infection, defined as positive antibodies in the IgA + IgM class, a higher percentage of patients with the presence of interleukin (IL) 2 (IL-2) was found. No association with other cytokines or effects of IBD activity or treatment was found. However, the effect of the applied treatment on the concentration of some cytokines was found: a negative association of infliximab, vedolizumab, and prednisone with IL-2, a positive correlation of steroids, thiopurines with IL-10, and in the case of tumor necrosis factor-α (TNF-α), negative with infliximab, and positive with vedolizumab.
The increased concentration of IL-2 may result from its regulatory role in inhibiting excessive activation of the immune system; however, considering the studies of patients with severe COVID-19, its role in the initial phase of SARS-CoV-2 infection requires further research. IntroductionAlthough the phenomenon of cytokine storm is well described in patients with severe COVID-19, little is known about the role of the immune system in asymptomatic patients, especially in the group with autoimmune diseases, such as inflammatory bowel disease (IBD).AimTo assess the stimulation of the immune system expressed through the production of cytokines in IBD patients with asymptomatic COVID-19.Material and methodsThis is a multi-centre, prospective study in which the concentration of many cytokines (IL-1a, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL- 15, IL-17, IL-23, IFN-γ, TNF-α, TNF-β) was assessed in patients with IBD and asymptomatic SARS-CoV-2 infection diagnosed by serological tests.ResultsIn the group of patients with a recent SARS-CoV-2 infection, defined as positive antibodies in the IgA + IgM class, a higher percentage of patients with the presence of interleukin (IL) 2 (IL-2) was found. No association with other cytokines or effects of IBD activity or treatment was found. However, the effect of the applied treatment on the concentration of some cytokines was found: a negative association of infliximab, vedolizumab, and prednisone with IL-2, a positive correlation of steroids, thiopurines with IL-10, and in the case of tumor necrosis factor-α (TNF-α), negative with infliximab, and positive with vedolizumab.ConclusionsThe increased concentration of IL-2 may result from its regulatory role in inhibiting excessive activation of the immune system; however, considering the studies of patients with severe COVID-19, its role in the initial phase of SARS-CoV-2 infection requires further research. |
Author | Łodyga, Michał Eder, Piotr Cicha, Małgorzata Stawczyk-Eder, Kamila Dobrowolska, Agnieszka Gąsiorowska, Anita Rydzewska, Grażyna Maciejewska, Katarzyna Wiśniewska-Jarosińska, Maria |
Author_xml | – sequence: 1 givenname: Michał surname: Łodyga fullname: Łodyga, Michał organization: Department of Internal Medicine, Faculty of Health Science, Medical University of Warsaw, Warsaw, Poland – sequence: 2 givenname: Katarzyna surname: Maciejewska fullname: Maciejewska, Katarzyna organization: Department of Gastroenterology with the Inflammatory Bowel Disease Subdivision, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland – sequence: 3 givenname: Kamila surname: Stawczyk-Eder fullname: Stawczyk-Eder, Kamila organization: Department of Gastroenterology, Dietetics, and Internal Medicine, Poznan University of Medical Sciences, Heliodor Święcicki University Hospital, Poznan, Poland – sequence: 4 givenname: Piotr surname: Eder fullname: Eder, Piotr organization: Department of Gastroenterology, Dietetics, and Internal Medicine, Poznan University of Medical Sciences, Heliodor Święcicki University Hospital, Poznan, Poland – sequence: 5 givenname: Agnieszka surname: Dobrowolska fullname: Dobrowolska, Agnieszka organization: Department of Gastroenterology, Dietetics, and Internal Medicine, Poznan University of Medical Sciences, Heliodor Święcicki University Hospital, Poznan, Poland – sequence: 6 givenname: Maria surname: Wiśniewska-Jarosińska fullname: Wiśniewska-Jarosińska, Maria organization: Department of Gastroenterology, Medical University of Lodz, Lodz, Poland – sequence: 7 givenname: Anita surname: Gąsiorowska fullname: Gąsiorowska, Anita organization: Department of Gastroenterology, Medical University of Lodz, Lodz, Poland – sequence: 8 givenname: Małgorzata surname: Cicha fullname: Cicha, Małgorzata organization: Diagnostic Laboratory, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland – sequence: 9 givenname: Grażyna surname: Rydzewska fullname: Rydzewska, Grażyna organization: Collegium Medicum, Jan Kochanowski University, Kielce, Poland |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38571543$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkUtv3CAUhVGVqnm02y4rlt14ytOYVRVN-hgpUjZtt-ja4BkiY1zDTOR_XyaTRM0KuPfw3ce5RGdjHB1CHylZSUrFl2m7YoTxFWWCNfQNuqCNVpXgVJ093mUllSLn6DKle0LqRhL6Dp3zRioqBb9Ah-uUXErBjRnHHuedw9Blf_B5eX77EPajw2lJ2QXsRzxB9kWf8IPPuxLoBwgBcpwX3MYHN2Drk4OCxTBaDGkJU45F4Du8vvuzuamofo_e9jAk9-HpvEK_v3_7tf5Z3d792Kyvb6tOSJUr1ghFtGhsXbdMQxlFabCd5UxzUKRXVlolWseFdK5mxPZAQLZlNldSdc-v0ObEtRHuzTT7APNiInjzGIjz1sBcGhucqSWDmmjSaV0Lqfum5ratBe-VYMeShfX1xJr2bXC2KyuYYXgFfZ0Z_c5s48FQosu-pS6Ez0-EOf7du5RN8KlzwwCji_tkOOGckEZIUqSrk7SbY0qz61_qUGKOzptpa47Om5Pz5cOn_7t7kT9bzf8B4Y2slw |
CitedBy_id | crossref_primary_10_3390_jcm12185956 crossref_primary_10_3390_jcm12103455 |
ContentType | Journal Article |
Copyright | Copyright © 2024 Termedia. Copyright © 2024 Termedia 2024 |
Copyright_xml | – notice: Copyright © 2024 Termedia. – notice: Copyright © 2024 Termedia 2024 |
DBID | NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.5114/pg.2023.124281 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1897-4317 |
EndPage | 53 |
ExternalDocumentID | oai_doaj_org_article_652a6090c996459f863db643f742dcd3 10_5114_pg_2023_124281 38571543 |
Genre | Journal Article |
GroupedDBID | 123 2NK 3V. 53G 5VS 7X7 88E 8FI 8FJ 8G5 ABUWG ADBBV ADRAZ AFKRA AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BCNDV BENPR BPHCQ BVXVI CCPQU DIK DWQXO FRP FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 HMCUK HYE IPNFZ KQ8 M1P M2O M48 NPM OK1 PADUT PGMZT PIMPY PQQKQ PROAC PSQYO RIG RPM UKHRP Y2W AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c457t-28470948d66b29a57779adcd3293a70f7d5d74be345ee620dfa0a5b715e7d56f3 |
IEDL.DBID | RPM |
ISSN | 1895-5770 |
IngestDate | Thu Jul 04 21:06:18 EDT 2024 Tue Sep 17 21:29:02 EDT 2024 Sat Aug 17 05:25:51 EDT 2024 Fri Aug 23 01:36:25 EDT 2024 Tue Aug 27 13:48:49 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | COVID-19 cytokines inflammatory bowel disease |
Language | English |
License | Copyright © 2024 Termedia. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/) |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c457t-28470948d66b29a57779adcd3293a70f7d5d74be345ee620dfa0a5b715e7d56f3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985759/ |
PMID | 38571543 |
PQID | 3033008450 |
PQPubID | 23479 |
PageCount | 8 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_652a6090c996459f863db643f742dcd3 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10985759 proquest_miscellaneous_3033008450 crossref_primary_10_5114_pg_2023_124281 pubmed_primary_38571543 |
PublicationCentury | 2000 |
PublicationDate | 2024-01-01 |
PublicationDateYYYYMMDD | 2024-01-01 |
PublicationDate_xml | – month: 01 year: 2024 text: 2024-01-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Poland |
PublicationPlace_xml | – name: Poland |
PublicationTitle | Przegląd gastroenterologiczny |
PublicationTitleAlternate | Prz Gastroenterol |
PublicationYear | 2024 |
Publisher | Termedia Publishing House |
Publisher_xml | – name: Termedia Publishing House |
SSID | ssj0068501 ssib005436634 |
Score | 2.3176458 |
Snippet | Although the phenomenon of cytokine storm is well described in patients with severe COVID-19, little is known about the role of the immune system in... IntroductionAlthough the phenomenon of cytokine storm is well described in patients with severe COVID-19, little is known about the role of the immune system... |
SourceID | doaj pubmedcentral proquest crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 46 |
SubjectTerms | covid-19 cytokines inflammatory bowel disease Original Paper |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NTxQxFG8IJy5EI-IqmpKYeBpopx_THhEhaKJcgHBr-ombyMyGXTD-9762s5tdY-LF47QzmfbXN_N7rx-_h9B7RpSnPrVN5CE1XAfWqETztr8kdKuciimfHf76TV5c8y-34nYt1VfeE1blgStwx1K0VhJNPDjmXOikJAsOaDRBTBd8qDqfVKwFU8WyOAMq5ct_slSiJEKmSotGdB2p8o3gbPDj2d1RTiF-BETXKrpBT0XF_2-u5587KNco6fwZ2h19SXxS-_AcbcX-BXo6WWlt4iFh8O9wPruQU0Qsr6f5TEjEVcQZT3s8iqvOcZ6VhYIEZnJflt-xG37GH3hcxplj2wds57_uZ4uhaL3i08ubz58aqvfQ9fnZ1elFMyZXaDwX3aLJtAShnQpSulZbAKXTNgMK_G87krogQsddZFzEKFsSkiVWuI6KCFUysZdoux_6-AphTbQLHvxfqzgnySvnaWRtlgaTkfs0QR-WmJpZ1dAwEHtk9M3szmT0TUV_gj5myFd3Ze3rUgAWYUaLMP-yiAk6XA6YgW8lL4DYPg6PcwN0zXICAUEmaL8O4OpVTAnoG4en1cbQbrRls6affi963JTokuf09f9o_Ru0A4DwOstzgLYXD4_xLfg9C_eumPhv14X-Ag priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQuXBBIF5LARkJiVMWJ37EPqFSqApS4cKi3iw_l5XaZNlsgf57ZpLs0kV75Bg7D3s8znxje74h5BVnOpQhV0USMRfCRF7oXOKxvyxNpb1OGWOHzz6r05n4dC7P_55_GgXY7XXtMJ_UbHUx_f3j-i1MeMCvU4AL4s1yPsUk4FMwVRVGYd-uBBeo7Wc3oL4UHIyr2PyllZZ9auRSG1nIumYDoeOe9-0YrJ7Xfx8Y_fdM5Q0jdXKP3B3RJT0a1OE-uZWaB-Tn0ZZ9k7aZAuKjGM2ASSM21wuMEkl0oHWmi4aOdKsdxXVaKMigOJf9hjz17a90QceNnY66JlLXXV8u123P_kqPv3z7-L4ozUMyO_nw9fi0GNMtFEHIel2goQJnT0elfGUcCKU2LobIARG4muU6ylgLn7iQKamKxeyYk74uZYIqlfkjctC0TXpCqGHGxwCI2GkhWA7ahzLxCsnCVBIhT8jrjUztcmDVsOCNoPTtcm5R-naQ_oS8Q5Fv70I27L6gXc3tOLmskpVTzLAAzpuQJmvFoweolcHvxw5MyMvNgFmYPbgl4prUXnUWDDjHlAKSTcjjYQC3n-JaQt8EPK13hnanLbs1zeJ7z9BdMtNnPn36P1p_SO6AQMSw7vOMHKxXV-k5IKG1f9Gr-B8hOwWR priority: 102 providerName: Scholars Portal |
Title | Assessment of the activity of the immune system in patients with inflammatory bowel diseases and asymptomatic COVID-19 |
URI | https://www.ncbi.nlm.nih.gov/pubmed/38571543 https://search.proquest.com/docview/3033008450 https://pubmed.ncbi.nlm.nih.gov/PMC10985759 https://doaj.org/article/652a6090c996459f863db643f742dcd3 |
Volume | 19 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe28cILAvFVPiojIfGU1ok_Yj9uZWMgdUyIob5F_uwqrUm0diD-e85OUtGJJ14sxY4V5-6Su7PvfofQe0qkzW0oMs9cyJhyNJMhj2F_gatCGulDzB2eX4jzK_ZlwRcHSAy5MClo35rVpL5ZT-rVdYqtbNd2OsSJTS_ns5yoVFhyeogOS0rv-eicUVCjbPgfC8lTEeRcKp7xsiQddCMYGmzaLiexfPgElFwh8z3VlBD8_2V23o-e_EsdnT1Gj3o7Eh93632CDnz9FP083uFs4iZgsO1wzFuI5SGG61XMB_G4A3DGqxr3wKobHHdkoSOAiKzT0Ts2zS9_g_sjnA3WtcN683vdbpuE84pnX398_pjl6hm6Ojv9PjvP-sIKmWW83GZRJYFbJ50QplAaiFIq7ayjoPt1SULpuCuZ8ZRx70VBXNBEc1Pm3MOQCPQ5Oqqb2r9EWBFlnAXbV0vGSLDS2NzTIsKCCc9sGKEPA02rtsPPqMDviNSv2mUVqV911B-hk0jy3V0R9zp1NLfLqud-JXihBVHEgpvGuApSUGfAqArg4ccXGKF3A8Mq-E7i4YeufXO3qUBV01g8gJMRetExcPcoCtIEpiTMlnus3VvL_giIZsLiHkTx1f9PfY0eAhlYt6_zBh1tb-_8W7B0tmYM4r0ox-jByenF5bdx2i-A9tMih3bO5DgJ_h8x8ANz |
link.rule.ids | 230,315,733,786,790,870,891,2115,2236,24346,27957,27958,31755,33780,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKOcCFh3hty8NISJySdeJH7GNZqLbQLRxa6C2KX8uKbhJ1syD49YzzWLErLnCMnSixZ5z5xp75BqFXlEiTGJ9GjlkfMWVpJH0Swv48V6nU0vmQOzw7E9ML9v6SX-4hMeTCtEH7Ri_i8moZl4uvbWxlvTTjIU5s_Gk2SYhqC0uOb6CbsGDTbMdL54yCIWXDH1lI3pZBTqTiEc8y0pE3AtRg43oehwLiMZi5VCZbxqnl8P8b8NyNn_zDIB3fRV-GoXRxKN_idaNj82uH5fHfx3oP3ekxKj7q-u-jPVc-QN-PNhyeuPIYcCMOORGh9MRwvQi5Jg535NB4UeKetHWFw24vNHhQv2V7rI919cNd4f54aIWL0uJi9XNZN1XLIYsnHz-fvI0S9RBdHL87n0yjvmhDZBjPmiiYO3AZpRVCp6qA6c5UYY2lgCuKjPjMcpsx7SjjzomUWF-Qguss4Q66hKeP0H5Zle4JwooobQ3g6kIyRryR2iSOpoFyTDhm_Ai9HqSV1x03Rw4-TZBrXs_zINe8k-sIvQnC3NwVOLXbhup6nveznQueFoIoYsAFZFx5KajVANh8xtIwgBF6OahCDmswHKwUpavWqxxgAA2FCTgZocedamxeRUF6AFPhabmlNFvfst0DqtDyfA-iP_j_R1-gW9Pz2Wl-enL24RDdhilh3f7RU7TfXK_dM0BUjX7eLp_fK5UgZw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagSIgLD_Ho8jQSEqdkncRO7GPZsmqBlh4oqsTB8nNZ0U2iJguCX884jxW74tRj_FBizzjzjT3-BqE3GeEmMT6NHLU-osJmEfdJCPvzTKRcc-fD3eGT0_zonH64YBdDVGUzhFWWRi_j8nIVl8vvXWxlvTLTMU5senYyS4joEktOa-unN9EtWLSp2PHUGc3AmNLxr5xz1qVCTrhgESsK0hM4Atyg03oRhyTiMZi6lCdbBqrj8f8f-NyNofzHKM3voW_jcPpYlB_xutWx-bPD9Hi98d5Hdwesig_6Ng_QDVc-RD8PNlyeuPIY8CMOdyNCCorxeRnunDjck0TjZYkH8tYGh11fKPCghqvueB_r6pe7xMMxUYNVabFqfq_qtuq4ZPHs89fjwygRj9D5_P2X2VE0JG-IDGVFGwWzB64jt3muU6FgyguhrLEZ4AtVEF9YZguqXUaZc3lKrFdEMV0kzEFV7rPHaK-sSrePsCBCWwP4WnFKiTdcm8RlaaAeyx01foLejhKTdc_RIcG3CbKV9UIG2cpethP0Lgh00ypwa3cF1dVCDjMuc5aqnAhiwBWkTHieZ1YDcPMFTcMAJuj1qA4S1mI4YFGlq9aNBDiQhQQFjEzQk149Nq_KQIIAV6E331KcrW_ZrgF16Pi-R_E_vX7XV-j22eFcfjo-_fgM3YEZof020nO0116t3QsAVq1-2a2gvypKIuc |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Assessment+of+the+activity+of+the+immune+system+in+patients+with+inflammatory+bowel+diseases+and+asymptomatic+COVID-19&rft.jtitle=Przegl%C4%85d+gastroenterologiczny&rft.au=Micha%C5%82+%C5%81odyga&rft.au=Katarzyna+Maciejewska&rft.au=Kamila+Stawczyk-Eder&rft.au=Piotr+Eder&rft.date=2024-01-01&rft.pub=Termedia+Publishing+House&rft.issn=1895-5770&rft.eissn=1897-4317&rft.volume=19&rft.issue=1&rft.spage=46&rft.epage=53&rft_id=info:doi/10.5114%2Fpg.2023.124281&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_652a6090c996459f863db643f742dcd3 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1895-5770&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1895-5770&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1895-5770&client=summon |