Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides
A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to be identical with one-pot synthesis by spectra...
Saved in:
Published in | European journal of medicinal chemistry Vol. 50; pp. 274 - 279 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
ISSY-LES-MOULINEAUX
Elsevier Masson SAS
01.04.2012
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to be identical with one-pot synthesis by spectral and analytical data. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines and in vivo anticancer activity on EAC-bearing mice. Compound 1a was found to be the most active both in in vitro and in vivo cytotoxic studies.
Multi-component synthesis of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides and their in vitro and in vivo anticancer activity was reported. [Display omitted]
► Novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides. ► Multi-component one-pot synthesis. ► In vitro and In vivo anticancer activity. ► Compounds 1a and 1h showed good in vivo anticancer activity. |
---|---|
AbstractList | A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to be identical with one-pot synthesis by spectral and analytical data. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines and in vivo anticancer activity on EAC-bearing mice. Compound 1a was found to be the most active both in in vitro and in vivo cytotoxic studies.
Multi-component synthesis of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides and their in vitro and in vivo anticancer activity was reported. [Display omitted]
► Novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides. ► Multi-component one-pot synthesis. ► In vitro and In vivo anticancer activity. ► Compounds 1a and 1h showed good in vivo anticancer activity. A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to be identical with one-pot synthesis by spectral and analytical data. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines and in vivo anticancer activity on EAC-bearing mice. Compound 1a was found to be the most active both in in vitro and in vivo cytotoxic studies. (C) 2012 Elsevier Masson SAS. All rights reserved. A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to be identical with one-pot synthesis by spectral and analytical data. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines and in vivo anticancer activity on EAC-bearing mice. Compound 1a was found to be the most active both in in vitro and in vivo cytotoxic studies. |
Author | Krishna, S. Rama Reddy, M. Nagi Narasimha Reddy, A. Ram Rajanarendar, E. Kiran, L. Hari Raju, S. Reddy, Y. Narasimha |
Author_xml | – sequence: 1 givenname: E. surname: Rajanarendar fullname: Rajanarendar, E. email: eligeti_rajan@yahoo.co.in organization: Department of Chemistry, Kakatiya University, Vidyaranyapuri, Warangal, A.P. 506 009, India – sequence: 2 givenname: S. surname: Raju fullname: Raju, S. organization: Department of Chemistry, Kakatiya University, Vidyaranyapuri, Warangal, A.P. 506 009, India – sequence: 3 givenname: M. Nagi surname: Reddy fullname: Reddy, M. Nagi organization: Department of Chemistry, Kakatiya University, Vidyaranyapuri, Warangal, A.P. 506 009, India – sequence: 4 givenname: S. Rama surname: Krishna fullname: Krishna, S. Rama organization: Department of Chemistry, Kakatiya University, Vidyaranyapuri, Warangal, A.P. 506 009, India – sequence: 5 givenname: L. Hari surname: Kiran fullname: Kiran, L. Hari organization: Department of Pharmacology and Toxicology, Kakatiya University, Warangal, A.P. 506 009, India – sequence: 6 givenname: A. Ram surname: Narasimha Reddy fullname: Narasimha Reddy, A. Ram organization: Department of Pharmacology and Toxicology, Kakatiya University, Warangal, A.P. 506 009, India – sequence: 7 givenname: Y. Narasimha surname: Reddy fullname: Reddy, Y. Narasimha organization: Department of Pharmacology and Toxicology, Kakatiya University, Warangal, A.P. 506 009, India |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25755353$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22377593$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkc2KFDEQgIOsuLOjbyDSF_GgPean05m-CDL4B6te9CQS0kk1k6E7GZP0uL33fQ-fxSczQ4-rJxEKkgpfVVJfLtCZ8w4QekjwimBSP9-tYDeA3q4oJnSFc-DqDloQUa9LRnl1hhaYUlZyyqpzdBHjDmPMa4zvofN8LgRv2ALdvB_7ZEvth31u71IRJ5e2EG0slDOFdT9_HGwK_q_scEyS1cppCIXSyWZiKnxXOH-AvlBh6gdI26kHB0VrY2mjv1LXvvdfqme8bL_up2CNdVB-KP2VNRDvo7ud6iM8OK1L9Pn1q0-bt-XlxzfvNi8vS11xkUpaq6oF6ARjYATmmuCKde1aG2a6umMc65qIxpiatCBUI6AG0HXbipZpoIwt0ZO57z74byPEJAcbNfS9cuDHKBvaENIILDJZzaQOPsYAndwHO-TRJMHy6F_u5OxfHv1LnCM_ZokenS4Y2wHMbdFv4Rl4fAJU1KrvQrZo4x-OC84ZP3LrmfsOre-itpBt32L5JxlmdF1VeUebjU0qWe82fnQplz79_9JMv5hpyN4PFoI8VRgbQCdpvP33yL8AbYHNBg |
CODEN | EJMCA5 |
CitedBy_id | crossref_primary_10_1002_chin_201235175 crossref_primary_10_1007_s13738_012_0197_x crossref_primary_10_1002_ajoc_202300562 crossref_primary_10_1016_j_bmcl_2015_01_041 crossref_primary_10_2174_1871520622666220324102849 crossref_primary_10_1002_slct_202101719 crossref_primary_10_1080_17518253_2017_1285966 crossref_primary_10_1002_jhet_2009 crossref_primary_10_1039_D0RA09072G crossref_primary_10_1016_j_tet_2023_133584 crossref_primary_10_1002_slct_201700640 crossref_primary_10_1070_RCR4503 crossref_primary_10_1002_slct_201700247 crossref_primary_10_1016_j_tetlet_2017_08_062 crossref_primary_10_1007_s13738_014_0438_2 crossref_primary_10_1016_j_ejmech_2016_09_023 crossref_primary_10_1016_j_jbiosc_2012_06_006 crossref_primary_10_2217_nnm_2016_0120 crossref_primary_10_1039_C7NJ01165B crossref_primary_10_1007_s10593_023_03186_y crossref_primary_10_1107_S1600536813013913 crossref_primary_10_1016_j_ejmech_2017_06_002 crossref_primary_10_1016_j_ejmech_2012_07_029 crossref_primary_10_1002_jhet_1908 crossref_primary_10_1016_j_cclet_2012_06_029 crossref_primary_10_1039_D4NJ00311J crossref_primary_10_1002_jhet_2064 crossref_primary_10_1016_j_cclet_2013_01_002 crossref_primary_10_1002_adsc_201500125 crossref_primary_10_1002_jhet_4524 crossref_primary_10_1080_17518253_2012_700736 crossref_primary_10_1134_S1070363221090255 crossref_primary_10_1016_j_tetlet_2017_11_027 crossref_primary_10_3987_COM_13_12802 crossref_primary_10_1002_jhet_2146 crossref_primary_10_1007_s13738_018_1410_3 crossref_primary_10_1007_s00044_016_1616_9 crossref_primary_10_1007_s10973_019_08548_3 crossref_primary_10_1002_ajoc_202000519 crossref_primary_10_1002_cbdv_202300752 crossref_primary_10_1016_j_ejmech_2017_12_096 crossref_primary_10_1002_adsc_202100239 crossref_primary_10_1021_acs_orglett_5b03462 crossref_primary_10_3762_bjoc_20_94 crossref_primary_10_1002_jhet_4473 crossref_primary_10_1002_adsc_202300217 crossref_primary_10_1007_s11030_018_9845_0 crossref_primary_10_1016_j_steroids_2013_10_003 crossref_primary_10_1016_j_bmcl_2012_08_098 crossref_primary_10_1080_23312009_2017_1318693 crossref_primary_10_1007_s00044_013_0598_0 crossref_primary_10_1016_j_bmcl_2013_04_053 crossref_primary_10_1016_j_ejmech_2023_115533 crossref_primary_10_1134_S1068162021060091 |
Cites_doi | 10.1128/AAC.47.9.2951-2957.2003 10.1093/jac/dkh530 10.1021/cr040648k 10.1016/j.canlet.2004.10.021 10.1002/anie.200460548 10.3998/ark.5550190.0008.e25 10.1016/j.drup.2006.05.003 10.1016/j.tetlet.2006.04.145 10.1021/cc049879v 10.1080/17415993.2010.492474 10.1016/j.semcancer.2005.04.004 10.1021/ol0477881 10.1021/ar000048h 10.1016/j.bmcl.2010.08.060 10.1021/ol020238n 10.1158/1535-7163.MCT-07-2037 10.1017/S1462399403005623 10.1016/S0165-2478(00)00208-X 10.1093/jnci/83.11.757 10.1351/pac200173010187 10.1002/1522-2675(200209)85:9<2961::AID-HLCA2961>3.0.CO;2-R 10.1002/jhet.5570440134 10.1016/S0367-326X(02)00232-0 10.1021/cr970413r 10.1093/jnci/82.13.1107 10.1248/cpb.58.833 10.2174/138161206779010477 10.1016/S0969-8051(00)00131-1 10.1055/s-2001-18074 |
ContentType | Journal Article |
Copyright | 2012 Elsevier Masson SAS 2015 INIST-CNRS Copyright © 2012 Elsevier Masson SAS. All rights reserved. |
Copyright_xml | – notice: 2012 Elsevier Masson SAS – notice: 2015 INIST-CNRS – notice: Copyright © 2012 Elsevier Masson SAS. All rights reserved. |
DBID | 1KM 1KN BLEPL DTL GKHJH IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.ejmech.2012.02.004 |
DatabaseName | Index Chemicus Current Chemical Reactions Web of Science Core Collection Science Citation Index Expanded Web of Science - Science Citation Index Expanded - 2012 Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | Web of Science MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | Web of Science MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 1KN name: Current Chemical Reactions url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.CCR sourceTypes: Enrichment Source Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Chemistry Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1768-3254 |
EndPage | 279 |
ExternalDocumentID | 10_1016_j_ejmech_2012_02_004 22377593 25755353 000303284400029 S0223523412000803 |
Genre | Journal Article |
GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 29G 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM 9JN AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARLI AATCM AAXUO AAYOK ABFNM ABFRF ABGSF ABJNI ABMAC ABOCM ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFO ACIUM ACNNM ACRLP ADBBV ADECG ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJSZI ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FLBIZ FNPLU FYGXN G-2 G-Q GBLVA HMS HMT HVGLF HZ~ IHE J1W KOM M2Y M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCB SCC SDF SDG SES SEW SOC SPC SPCBC SPT SSK SSP SSU SSZ T5K WUQ ~G- 1KM 1KN AAXKI AKRWK BLEPL DTL GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED AAPBV ABPIF ABPTK IQODW AFJKZ CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c457t-26a4beef733ed705c1043fb8cd3df6f350c6179dd61be7a97e6eec6bb7b3ce233 |
IEDL.DBID | AIKHN |
ISICitedReferencesCount | 67 |
ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000303284400029 |
ISSN | 0223-5234 |
IngestDate | Fri Aug 16 23:24:54 EDT 2024 Thu Sep 26 18:17:17 EDT 2024 Sat Sep 28 08:06:17 EDT 2024 Sun Oct 22 16:07:15 EDT 2023 Fri Oct 18 19:39:26 EDT 2024 Tue Sep 17 23:56:06 EDT 2024 Fri Feb 23 02:33:48 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Multi-component synthesis Novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides In vivo anticancer activity In vitro anticancer activity INHIBITION In vivo anticancer activity NITRIC-OXIDE MOSQUITO LARVICIDAL ACTIVITY In vitro anticancer activity HUMAN-IMMUNODEFICIENCY-VIRUS DERIVATIVES Adenocarcinoma Antineoplastic agent Intraperitoneal administration Nitrone Spontaneous Cytotoxicity pyridine-N-oxides Uterine cervix Novel arylmethylene bis-isoxazolo[4,5-b] Structure activity relation Bicyclic compound Mammary gland Chemical synthesis Tumor cell Oxygen nitrogen heterocycle Human Rodentia Benzene derivatives Malignant tumor In vitro Hela cell line Mammary gland diseases In vivo Vertebrata Chemotherapy Mammalia Treatment Cell line Mouse Animal Ehrlich ascites tumor Cancer |
Language | English |
License | CC BY 4.0 Copyright © 2012 Elsevier Masson SAS. All rights reserved. |
LinkModel | DirectLink |
LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
MergedId | FETCHMERGED-LOGICAL-c457t-26a4beef733ed705c1043fb8cd3df6f350c6179dd61be7a97e6eec6bb7b3ce233 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 22377593 |
PQID | 929119707 |
PQPubID | 23479 |
PageCount | 6 |
ParticipantIDs | pubmed_primary_22377593 crossref_primary_10_1016_j_ejmech_2012_02_004 webofscience_primary_000303284400029CitationCount webofscience_primary_000303284400029 elsevier_sciencedirect_doi_10_1016_j_ejmech_2012_02_004 pascalfrancis_primary_25755353 proquest_miscellaneous_929119707 |
PublicationCentury | 2000 |
PublicationDate | 2012-04-01 |
PublicationDateYYYYMMDD | 2012-04-01 |
PublicationDate_xml | – month: 04 year: 2012 text: 2012-04-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | ISSY-LES-MOULINEAUX |
PublicationPlace_xml | – name: ISSY-LES-MOULINEAUX – name: Kidlington – name: France |
PublicationTitle | European journal of medicinal chemistry |
PublicationTitleAbbrev | EUR J MED CHEM |
PublicationTitleAlternate | Eur J Med Chem |
PublicationYear | 2012 |
Publisher | Elsevier Masson SAS Elsevier |
Publisher_xml | – name: Elsevier Masson SAS – name: Elsevier |
References | Mitra, Singh, Khar (bib11) 2003; 13 Rajanarendar, Raju, Siva Rami Reddy, Govardhan Reddy, Nagireddy (bib27) 2010; 58 Monks, Scudiero, Shekan, Shoemaker, Panil, Vistica, Hose, Langley, Cronise (bib29) 1991; 83 Fayol, Zhu (bib6) 2005; 7 Balzarini, Stevens, De Clercq, Schols, Pannecouque (bib17) 2005; 55 Loughlin, Tyndall, Glenn, Fairlie (bib9) 2004; 104 Hazra, Sarkar, Bhattacharya, Roy (bib32) 2002; 73 Rajanarendar, Mohan, Ramesh, Srinivas (bib23) 2007; 44 Kappe (bib3) 2000; 33 Rajanarendar, Ramesh, Kalyan Rao, Mohan, Srinivas (bib22) 2007; 14 Maksimovic-Ivanic, Mijatovic, Harhaji, Miljkovic, Dabideen, Cheng, Mangano, Malaponte, Al-abed, Libra, Garotta, Nicoletti, Stosic-Grujicic (bib18) 2008; 7 Li, Wogan (bib14) 2005; 226 Seruga, Barbero, Marquez (bib30) 2000; 74 Stevens, Pannecouque, De Clercq (bib16) 2003; 47 Eilbracht, Barfacker, Buss, Hollmann, Kitsos-Rzychon, Kranemann, Rische, Roggenbuck, Schimdt (bib1) 1999; 99 Rajanarendar, Nagireddy, Rama Murthy, Govardhan Reddy, Raju, Srinivas, Praveen, Srinivasa Rao (bib19) 2010; 20 Bonavida, Khineche, Huerta-Yepez, Garban (bib13) 2002; 9 Rajanarendar, Rao, Shaik, Nagireddy, Srinivas (bib20) 2010; 31 Tarr, Eggleton, Winyard (bib10) 2006; 12 Rajanarendar, Mohan, Rao, Reddy, Praveen, Rao (bib21) 2008; 47B Rajanarendar, Mohan, Ramesh, Karunakar (bib24) 2006; 47 Shimura, Musya, Hashimoto, Kojima, Kubodera, Sasaki (bib31) 2000; 27 Balzarini, Stevens, Andrei (bib15) 2002; 85 Sperry, Wright (bib7) 2005; 8 Murthy, Rao, Rao (bib26) 1973; 11 Ugi (bib4) 2001; 73 Lechner, Lirk, Rieder (bib12) 2005; 15 Ziegert, Toraeng, Knepper, Braese (bib8) 2005; 7 Ramon, Yus (bib5) 2005; 44 Bora, Saikia, Boruah (bib2) 2003; 5 Shekan, Storeng, Scudiero, Monks, Mc Mohan, Vistica, Warren, Bokesch, Kenney, Boyd (bib28) 1990; 82 List (bib25) 2001; 11 Bora, U (WOS:000181077200014) 2003; 5 Ugi, I (WOS:000168165700027) 2001; 73 Rajanarendar, E (WOS:000251574400025) 2007 Ziegert, RE (WOS:000227708100001) 2005; 7 Fayol, A (WOS:000226330300019) 2005; 7 Eilbracht, P (WOS:000083794800006) 1999; 99 SKEHAN, P (WOS:A1990DL34800004) 1990; 82 Segura, JA (WOS:000089505400003) 2000; 74 Li, CQ (WOS:000230766400001) 2005; 226 Tarr, JM (WOS:000242331600004) 2006; 12 Stevens, M (WOS:000184988000036) 2003; 47 Mitra, R. (000303284400029.14) 2003; 13 Rajanarendar, E (WOS:000238629400037) 2006; 47 Loughlin, WA (WOS:000225757500009) 2004; 104 Ramon, DJ (WOS:000227684200008) 2005; 44 Maksimovic-Ivanic, D (WOS:000254312800009) 2008; 7 Rajanarendar, E (WOS:000281963700021) 2010; 20 Hazra, B (WOS:000179933400034) 2002; 73 Balzarini, J (WOS:000178628100031) 2002; 85 Shimura, N (WOS:000165113200008) 2000; 27 Balzarini, J (WOS:000226612200001) 2005; 55 Rajanarendar, E (WOS:000244120000034) 2007; 44 Lechner, M (WOS:000231336200005) 2005; 15 List, B (WOS:000172040300002) 2001 Bonavida, B (WOS:000240729100006) 2006; 9 Rajanarendar, E (WOS:000256092600011) 2008; 47 Rajanarendar, E (WOS:000278131700010) 2010; 58 Rajanarendar, E (WOS:000281064800004) 2010; 31 Kappe, CO (WOS:000166180700008) 2000; 33 MONKS, A (WOS:A1991FN23400012) 1991; 83 Sperry, JB (WOS:000233331700005) 2005; 8 MURTY, AK (WOS:A1973R986700052) 1973; 11 Balzarini (10.1016/j.ejmech.2012.02.004_bib15) 2002; 85 Ugi (10.1016/j.ejmech.2012.02.004_bib4) 2001; 73 Stevens (10.1016/j.ejmech.2012.02.004_bib16) 2003; 47 Rajanarendar (10.1016/j.ejmech.2012.02.004_bib24) 2006; 47 Seruga (10.1016/j.ejmech.2012.02.004_bib30) 2000; 74 Mitra (10.1016/j.ejmech.2012.02.004_bib11) 2003; 13 Fayol (10.1016/j.ejmech.2012.02.004_bib6) 2005; 7 Li (10.1016/j.ejmech.2012.02.004_bib14) 2005; 226 Bora (10.1016/j.ejmech.2012.02.004_bib2) 2003; 5 Eilbracht (10.1016/j.ejmech.2012.02.004_bib1) 1999; 99 Rajanarendar (10.1016/j.ejmech.2012.02.004_bib27) 2010; 58 Hazra (10.1016/j.ejmech.2012.02.004_bib32) 2002; 73 Maksimovic-Ivanic (10.1016/j.ejmech.2012.02.004_bib18) 2008; 7 Sperry (10.1016/j.ejmech.2012.02.004_bib7) 2005; 8 Loughlin (10.1016/j.ejmech.2012.02.004_bib9) 2004; 104 Shekan (10.1016/j.ejmech.2012.02.004_bib28) 1990; 82 Rajanarendar (10.1016/j.ejmech.2012.02.004_bib21) 2008; 47B Bonavida (10.1016/j.ejmech.2012.02.004_bib13) 2002; 9 Rajanarendar (10.1016/j.ejmech.2012.02.004_bib20) 2010; 31 List (10.1016/j.ejmech.2012.02.004_bib25) 2001; 11 Lechner (10.1016/j.ejmech.2012.02.004_bib12) 2005; 15 Balzarini (10.1016/j.ejmech.2012.02.004_bib17) 2005; 55 Rajanarendar (10.1016/j.ejmech.2012.02.004_bib23) 2007; 44 Rajanarendar (10.1016/j.ejmech.2012.02.004_bib19) 2010; 20 Monks (10.1016/j.ejmech.2012.02.004_bib29) 1991; 83 Rajanarendar (10.1016/j.ejmech.2012.02.004_bib22) 2007; 14 Shimura (10.1016/j.ejmech.2012.02.004_bib31) 2000; 27 Ramon (10.1016/j.ejmech.2012.02.004_bib5) 2005; 44 Tarr (10.1016/j.ejmech.2012.02.004_bib10) 2006; 12 Kappe (10.1016/j.ejmech.2012.02.004_bib3) 2000; 33 Murthy (10.1016/j.ejmech.2012.02.004_bib26) 1973; 11 Ziegert (10.1016/j.ejmech.2012.02.004_bib8) 2005; 7 |
References_xml | – volume: 85 start-page: 2961 year: 2002 ident: bib15 publication-title: Helevetica Chimica Acta contributor: fullname: Andrei – volume: 13 start-page: 1 year: 2003 ident: bib11 publication-title: Expert. Rev. Mol. Med. contributor: fullname: Khar – volume: 226 start-page: 1 year: 2005 ident: bib14 publication-title: Cancer. Lett. contributor: fullname: Wogan – volume: 58 start-page: 833 year: 2010 ident: bib27 publication-title: Chem. Pharm. Bull. contributor: fullname: Nagireddy – volume: 83 start-page: 757 year: 1991 ident: bib29 publication-title: J. Natl. Cancer Inst. contributor: fullname: Cronise – volume: 5 start-page: 435 year: 2003 ident: bib2 publication-title: Org. Lett. contributor: fullname: Boruah – volume: 47 start-page: 4957 year: 2006 ident: bib24 publication-title: Tetrahedron Lett. contributor: fullname: Karunakar – volume: 11 start-page: 1675 year: 2001 ident: bib25 publication-title: Synlett. contributor: fullname: List – volume: 11 start-page: 1074 year: 1973 ident: bib26 publication-title: Indian J. Chem. contributor: fullname: Rao – volume: 7 start-page: 147 year: 2005 ident: bib8 publication-title: J. Comb. Chem. contributor: fullname: Braese – volume: 44 start-page: 215 year: 2007 ident: bib23 publication-title: J. Heterocycl. Chem. contributor: fullname: Srinivas – volume: 12 start-page: 4445 year: 2006 ident: bib10 publication-title: Curr. Pharm. Des. contributor: fullname: Winyard – volume: 104 start-page: 6085 year: 2004 ident: bib9 publication-title: Chem. Rev. contributor: fullname: Fairlie – volume: 7 start-page: 239 year: 2005 ident: bib6 publication-title: Org. Lett. contributor: fullname: Zhu – volume: 73 start-page: 187 year: 2001 ident: bib4 publication-title: Pure. Appl. Chem. contributor: fullname: Ugi – volume: 74 start-page: 111 year: 2000 ident: bib30 publication-title: Immunol. Lett. contributor: fullname: Marquez – volume: 55 start-page: 135 year: 2005 ident: bib17 publication-title: J. Antimicrob. Chemother. contributor: fullname: Pannecouque – volume: 47 start-page: 2951 year: 2003 ident: bib16 publication-title: Antimicrob. Agents Chemother. contributor: fullname: De Clercq – volume: 99 start-page: 3329 year: 1999 ident: bib1 publication-title: Chem. Rev. contributor: fullname: Schimdt – volume: 73 start-page: 730 year: 2002 ident: bib32 publication-title: Fitoterapia contributor: fullname: Roy – volume: 7 start-page: 510 year: 2008 ident: bib18 publication-title: Mol. Cancer. Ther. contributor: fullname: Stosic-Grujicic – volume: 8 start-page: 723 year: 2005 ident: bib7 publication-title: Curr. Opin. Drug Discor. Devel. contributor: fullname: Wright – volume: 31 start-page: 263 year: 2010 ident: bib20 publication-title: J. Sulfur Chem. contributor: fullname: Srinivas – volume: 33 start-page: 879 year: 2000 ident: bib3 publication-title: Acc. Chem. Res. contributor: fullname: Kappe – volume: 27 start-page: 577 year: 2000 ident: bib31 publication-title: Nuclear Med. Biol. contributor: fullname: Sasaki – volume: 15 start-page: 277 year: 2005 ident: bib12 publication-title: Semin. Cancer. Biol. contributor: fullname: Rieder – volume: 9 start-page: 157 year: 2002 ident: bib13 publication-title: Drug. Resist. Updat. contributor: fullname: Garban – volume: 82 start-page: 1107 year: 1990 ident: bib28 publication-title: J. Natl. Cancer Inst. contributor: fullname: Boyd – volume: 20 start-page: 6052 year: 2010 ident: bib19 publication-title: Bioorg. Med. Chem. Lett. contributor: fullname: Srinivasa Rao – volume: 47B start-page: 781 year: 2008 ident: bib21 publication-title: Indian J. Chem. contributor: fullname: Rao – volume: 44 start-page: 1602 year: 2005 ident: bib5 publication-title: Angew. Chem. Int. Ed. contributor: fullname: Yus – volume: 14 start-page: 266 year: 2007 ident: bib22 publication-title: Arkivoc contributor: fullname: Srinivas – volume: 82 start-page: 1107 year: 1990 ident: WOS:A1990DL34800004 article-title: NEW COLORIMETRIC CYTOTOXICITY ASSAY FOR ANTICANCER-DRUG SCREENING publication-title: JOURNAL OF THE NATIONAL CANCER INSTITUTE contributor: fullname: SKEHAN, P – volume: 47 start-page: 2951 year: 2003 ident: WOS:000184988000036 article-title: Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives publication-title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY doi: 10.1128/AAC.47.9.2951-2957.2003 contributor: fullname: Stevens, M – volume: 55 start-page: 135 year: 2005 ident: WOS:000226612200001 article-title: Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action publication-title: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY doi: 10.1093/jac/dkh530 contributor: fullname: Balzarini, J – volume: 104 start-page: 6085 year: 2004 ident: WOS:000225757500009 article-title: Beta-strand mimetics publication-title: CHEMICAL REVIEWS doi: 10.1021/cr040648k contributor: fullname: Loughlin, WA – volume: 226 start-page: 1 year: 2005 ident: WOS:000230766400001 article-title: Nitric oxide as a modulator of apoptosis publication-title: CANCER LETTERS doi: 10.1016/j.canlet.2004.10.021 contributor: fullname: Li, CQ – volume: 44 start-page: 1602 year: 2005 ident: WOS:000227684200008 article-title: Asymmetric multicomponent reactions (AMCRs): The new frontier publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION doi: 10.1002/anie.200460548 contributor: fullname: Ramon, DJ – start-page: 266 year: 2007 ident: WOS:000251574400025 article-title: p-TsOH catalysed KSF solid supported Michael addition with substituted isoxazoles and their reductive cyclisation to isoxazolo[4,5-b]azepines publication-title: ARKIVOC doi: 10.3998/ark.5550190.0008.e25 contributor: fullname: Rajanarendar, E – volume: 11 start-page: 1074 year: 1973 ident: WOS:A1973R986700052 article-title: SPECTROSCOPIC EVIDENCE FOR FORMATION OF 5-STYRYL DERIVATIVES DURING CONDENSATION OF 3,5-DIMETHYL-4-NITROISOXAZOLE WITH ALDEHYDES publication-title: INDIAN JOURNAL OF CHEMISTRY contributor: fullname: MURTY, AK – volume: 9 start-page: 157 year: 2006 ident: WOS:000240729100006 article-title: Therapeutic potential of nitric oxide in cancer publication-title: DRUG RESISTANCE UPDATES doi: 10.1016/j.drup.2006.05.003 contributor: fullname: Bonavida, B – volume: 47 start-page: 4957 year: 2006 ident: WOS:000238629400037 article-title: A one-pot synthesis of 3-methyl-5-aryl-4H-pyrrolo[2,3-d]-isoxazoles publication-title: TETRAHEDRON LETTERS doi: 10.1016/j.tetlet.2006.04.145 contributor: fullname: Rajanarendar, E – volume: 12 start-page: 4445 year: 2006 ident: WOS:000242331600004 article-title: Nitric oxide and the regulation of apoptosis in tumour cells publication-title: CURRENT PHARMACEUTICAL DESIGN contributor: fullname: Tarr, JM – volume: 27 start-page: 577 year: 2000 ident: WOS:000165113200008 article-title: Usefulness of Tc-99m-d,l-HMPAO for estimation of GSH content in tumor tissues publication-title: NUCLEAR MEDICINE AND BIOLOGY contributor: fullname: Shimura, N – volume: 7 start-page: 147 year: 2005 ident: WOS:000227708100001 article-title: The recent impact of solid-phase synthesis on medicinally relevant benzoannelated oxygen heterocycles publication-title: JOURNAL OF COMBINATORIAL CHEMISTRY doi: 10.1021/cc049879v contributor: fullname: Ziegert, RE – volume: 31 start-page: 263 year: 2010 ident: WOS:000281064800004 article-title: Design, synthesis, antibacterial and antifungal activity of novel spiro-isoxazolyl bis-[5,5']thiazolidin-4-ones and spiro-isoxazolyl thiazolidin-4-one-[5,5']-1,2-4 oxdiazolines publication-title: JOURNAL OF SULFUR CHEMISTRY doi: 10.1080/17415993.2010.492474 contributor: fullname: Rajanarendar, E – volume: 15 start-page: 277 year: 2005 ident: WOS:000231336200005 article-title: Inducible nitric oxide synthase (iNOS) in tumor biology: The two sides of the same coin. publication-title: SEMINARS IN CANCER BIOLOGY doi: 10.1016/j.semcancer.2005.04.004 contributor: fullname: Lechner, M – volume: 7 start-page: 239 year: 2005 ident: WOS:000226330300019 article-title: Three-component synthesis of polysubstituted 6-azaindolines and its tricyclic derivatives publication-title: ORGANIC LETTERS doi: 10.1021/ol0477881 contributor: fullname: Fayol, A – volume: 58 start-page: 833 year: 2010 ident: WOS:000278131700010 article-title: A Fast and Highly Efficient Protocol for Synthesis of Pyrrolo[2,3-d]isoxazoles and a New Series of Novel Benzyl Bis-pyrrolo[2,3-d]isoxazoles Using Task-Specific Ionic Liquids as Catalyst and Green Solvent publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN contributor: fullname: Rajanarendar, E – volume: 73 start-page: 187 year: 2001 ident: WOS:000168165700027 article-title: Recent progress in the chemistry of multicomponent reactions publication-title: PURE AND APPLIED CHEMISTRY contributor: fullname: Ugi, I – volume: 47 start-page: 781 year: 2008 ident: WOS:000256092600011 article-title: Synthesis, antimicrobial and mosquito larvicidal activity of N-protected amino acid/peptide isoxazoles publication-title: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY contributor: fullname: Rajanarendar, E – volume: 33 start-page: 879 year: 2000 ident: WOS:000166180700008 article-title: Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog publication-title: ACCOUNTS OF CHEMICAL RESEARCH doi: 10.1021/ar000048h contributor: fullname: Kappe, CO – volume: 13 start-page: 1 year: 2003 ident: 000303284400029.14 publication-title: Expert. Rev. Mol. Med contributor: fullname: Mitra, R. – volume: 20 start-page: 6052 year: 2010 ident: WOS:000281963700021 article-title: Synthesis, antimicrobial, and mosquito larvicidal activity of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS doi: 10.1016/j.bmcl.2010.08.060 contributor: fullname: Rajanarendar, E – volume: 85 start-page: 2961 year: 2002 ident: WOS:000178628100031 article-title: Pridine oxide derivatives: Structure-activity relationship for inhibition of human immunodeficiency virus and cytomegalovirus replication in cell culture publication-title: HELVETICA CHIMICA ACTA contributor: fullname: Balzarini, J – volume: 73 start-page: 730 year: 2002 ident: WOS:000179933400034 article-title: Tumour inhibitory activity of chicory root extract against Ehrlich ascites carcinoma in mice publication-title: FITOTERAPIA contributor: fullname: Hazra, B – volume: 8 start-page: 723 year: 2005 ident: WOS:000233331700005 article-title: Furans, thiophenes and related heterocycles in drug discovery publication-title: CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT contributor: fullname: Sperry, JB – volume: 44 start-page: 215 year: 2007 ident: WOS:000244120000034 article-title: Phase transfer catalyzed synthesis of 3-methyl-4H-pyrazolo[3,4-d]isoxazole from 3,5-dimethyl-4-isoxazolyldiazonium tetrafluoroborate publication-title: JOURNAL OF HETEROCYCLIC CHEMISTRY contributor: fullname: Rajanarendar, E – start-page: 1675 year: 2001 ident: WOS:000172040300002 article-title: Asymmetric aminocatalysis publication-title: SYNLETT contributor: fullname: List, B – volume: 74 start-page: 111 year: 2000 ident: WOS:000089505400003 article-title: Ehrlich ascites tumour unbalances splenic cell populations and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation publication-title: IMMUNOLOGY LETTERS contributor: fullname: Segura, JA – volume: 83 start-page: 757 year: 1991 ident: WOS:A1991FN23400012 article-title: FEASIBILITY OF A HIGH-FLUX ANTICANCER DRUG SCREEN USING A DIVERSE PANEL OF CULTURED HUMAN TUMOR-CELL LINES publication-title: JOURNAL OF THE NATIONAL CANCER INSTITUTE contributor: fullname: MONKS, A – volume: 99 start-page: 3329 year: 1999 ident: WOS:000083794800006 article-title: Tandem reaction sequences under hydroformylation conditions: New synthetic applications of transition metal catalysis publication-title: CHEMICAL REVIEWS contributor: fullname: Eilbracht, P – volume: 5 start-page: 435 year: 2003 ident: WOS:000181077200014 article-title: A novel microwave-mediated one-pot synthesis of indolizines via a three-component reaction publication-title: ORGANIC LETTERS doi: 10.1021/ol020238n contributor: fullname: Bora, U – volume: 7 start-page: 510 year: 2008 ident: WOS:000254312800009 article-title: Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo publication-title: MOLECULAR CANCER THERAPEUTICS doi: 10.1158/1535-7163.MCT-07-2037 contributor: fullname: Maksimovic-Ivanic, D – volume: 5 start-page: 435 year: 2003 ident: 10.1016/j.ejmech.2012.02.004_bib2 publication-title: Org. Lett. doi: 10.1021/ol020238n contributor: fullname: Bora – volume: 13 start-page: 1 year: 2003 ident: 10.1016/j.ejmech.2012.02.004_bib11 publication-title: Expert. Rev. Mol. Med. doi: 10.1017/S1462399403005623 contributor: fullname: Mitra – volume: 74 start-page: 111 year: 2000 ident: 10.1016/j.ejmech.2012.02.004_bib30 publication-title: Immunol. Lett. doi: 10.1016/S0165-2478(00)00208-X contributor: fullname: Seruga – volume: 83 start-page: 757 year: 1991 ident: 10.1016/j.ejmech.2012.02.004_bib29 publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/83.11.757 contributor: fullname: Monks – volume: 14 start-page: 266 year: 2007 ident: 10.1016/j.ejmech.2012.02.004_bib22 publication-title: Arkivoc doi: 10.3998/ark.5550190.0008.e25 contributor: fullname: Rajanarendar – volume: 73 start-page: 187 year: 2001 ident: 10.1016/j.ejmech.2012.02.004_bib4 publication-title: Pure. Appl. Chem. doi: 10.1351/pac200173010187 contributor: fullname: Ugi – volume: 104 start-page: 6085 year: 2004 ident: 10.1016/j.ejmech.2012.02.004_bib9 publication-title: Chem. Rev. doi: 10.1021/cr040648k contributor: fullname: Loughlin – volume: 7 start-page: 510 year: 2008 ident: 10.1016/j.ejmech.2012.02.004_bib18 publication-title: Mol. Cancer. Ther. doi: 10.1158/1535-7163.MCT-07-2037 contributor: fullname: Maksimovic-Ivanic – volume: 85 start-page: 2961 year: 2002 ident: 10.1016/j.ejmech.2012.02.004_bib15 publication-title: Helevetica Chimica Acta doi: 10.1002/1522-2675(200209)85:9<2961::AID-HLCA2961>3.0.CO;2-R contributor: fullname: Balzarini – volume: 31 start-page: 263 year: 2010 ident: 10.1016/j.ejmech.2012.02.004_bib20 publication-title: J. Sulfur Chem. doi: 10.1080/17415993.2010.492474 contributor: fullname: Rajanarendar – volume: 47 start-page: 4957 year: 2006 ident: 10.1016/j.ejmech.2012.02.004_bib24 publication-title: Tetrahedron Lett. doi: 10.1016/j.tetlet.2006.04.145 contributor: fullname: Rajanarendar – volume: 44 start-page: 215 year: 2007 ident: 10.1016/j.ejmech.2012.02.004_bib23 publication-title: J. Heterocycl. Chem. doi: 10.1002/jhet.5570440134 contributor: fullname: Rajanarendar – volume: 73 start-page: 730 year: 2002 ident: 10.1016/j.ejmech.2012.02.004_bib32 publication-title: Fitoterapia doi: 10.1016/S0367-326X(02)00232-0 contributor: fullname: Hazra – volume: 7 start-page: 239 year: 2005 ident: 10.1016/j.ejmech.2012.02.004_bib6 publication-title: Org. Lett. doi: 10.1021/ol0477881 contributor: fullname: Fayol – volume: 99 start-page: 3329 year: 1999 ident: 10.1016/j.ejmech.2012.02.004_bib1 publication-title: Chem. Rev. doi: 10.1021/cr970413r contributor: fullname: Eilbracht – volume: 11 start-page: 1074 year: 1973 ident: 10.1016/j.ejmech.2012.02.004_bib26 publication-title: Indian J. Chem. contributor: fullname: Murthy – volume: 7 start-page: 147 year: 2005 ident: 10.1016/j.ejmech.2012.02.004_bib8 publication-title: J. Comb. Chem. doi: 10.1021/cc049879v contributor: fullname: Ziegert – volume: 44 start-page: 1602 year: 2005 ident: 10.1016/j.ejmech.2012.02.004_bib5 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.200460548 contributor: fullname: Ramon – volume: 82 start-page: 1107 year: 1990 ident: 10.1016/j.ejmech.2012.02.004_bib28 publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/82.13.1107 contributor: fullname: Shekan – volume: 226 start-page: 1 year: 2005 ident: 10.1016/j.ejmech.2012.02.004_bib14 publication-title: Cancer. Lett. doi: 10.1016/j.canlet.2004.10.021 contributor: fullname: Li – volume: 47 start-page: 2951 year: 2003 ident: 10.1016/j.ejmech.2012.02.004_bib16 publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.47.9.2951-2957.2003 contributor: fullname: Stevens – volume: 58 start-page: 833 issue: 6 year: 2010 ident: 10.1016/j.ejmech.2012.02.004_bib27 publication-title: Chem. Pharm. Bull. doi: 10.1248/cpb.58.833 contributor: fullname: Rajanarendar – volume: 9 start-page: 157 year: 2002 ident: 10.1016/j.ejmech.2012.02.004_bib13 publication-title: Drug. Resist. Updat. doi: 10.1016/j.drup.2006.05.003 contributor: fullname: Bonavida – volume: 8 start-page: 723 year: 2005 ident: 10.1016/j.ejmech.2012.02.004_bib7 publication-title: Curr. Opin. Drug Discor. Devel. contributor: fullname: Sperry – volume: 55 start-page: 135 year: 2005 ident: 10.1016/j.ejmech.2012.02.004_bib17 publication-title: J. Antimicrob. Chemother. doi: 10.1093/jac/dkh530 contributor: fullname: Balzarini – volume: 12 start-page: 4445 year: 2006 ident: 10.1016/j.ejmech.2012.02.004_bib10 publication-title: Curr. Pharm. Des. doi: 10.2174/138161206779010477 contributor: fullname: Tarr – volume: 33 start-page: 879 year: 2000 ident: 10.1016/j.ejmech.2012.02.004_bib3 publication-title: Acc. Chem. Res. doi: 10.1021/ar000048h contributor: fullname: Kappe – volume: 27 start-page: 577 year: 2000 ident: 10.1016/j.ejmech.2012.02.004_bib31 publication-title: Nuclear Med. Biol. doi: 10.1016/S0969-8051(00)00131-1 contributor: fullname: Shimura – volume: 20 start-page: 6052 year: 2010 ident: 10.1016/j.ejmech.2012.02.004_bib19 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2010.08.060 contributor: fullname: Rajanarendar – volume: 11 start-page: 1675 year: 2001 ident: 10.1016/j.ejmech.2012.02.004_bib25 publication-title: Synlett. doi: 10.1055/s-2001-18074 contributor: fullname: List – volume: 15 start-page: 277 year: 2005 ident: 10.1016/j.ejmech.2012.02.004_bib12 publication-title: Semin. Cancer. Biol. doi: 10.1016/j.semcancer.2005.04.004 contributor: fullname: Lechner – volume: 47B start-page: 781 year: 2008 ident: 10.1016/j.ejmech.2012.02.004_bib21 publication-title: Indian J. Chem. contributor: fullname: Rajanarendar |
SSID | ssj0005600 |
Score | 2.3492835 |
Snippet | A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially... |
Source | Web of Science |
SourceID | proquest crossref pubmed pascalfrancis webofscience elsevier |
SourceType | Aggregation Database Index Database Enrichment Source Publisher |
StartPage | 274 |
SubjectTerms | Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Biological and medical sciences Chemistry, Medicinal Cyclic N-Oxides - chemical synthesis Cyclic N-Oxides - pharmacology Drug Screening Assays, Antitumor Female General aspects Humans In Vitro Techniques In vitro anticancer activity In vivo anticancer activity Isoxazoles - chemical synthesis Isoxazoles - pharmacology Life Sciences & Biomedicine Medical sciences Mice Molecular Structure Multi-component synthesis Neoplasms - drug therapy Novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides Pharmacology & Pharmacy Pharmacology. Drug treatments Science & Technology Structure-Activity Relationship Tumor Cells, Cultured |
Title | Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides |
URI | https://dx.doi.org/10.1016/j.ejmech.2012.02.004 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000303284400029 https://www.ncbi.nlm.nih.gov/pubmed/22377593 https://search.proquest.com/docview/929119707 |
Volume | 50 |
WOS | 000303284400029 |
WOSCitedRecordID | wos000303284400029 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9RAFD602wcFEa1a42WZh9KnHTfJ3DaPZbGsikvBFgoiYSaZQEpNls12aXzwzf_hb_GXeSaXbgsVRcjLJDNJZs7kfN9kzgVgP0XUCzmTNNViQnk0MfhJSU11ZERotIxk4PydP87l7JS_PxNnWzDtfWGcWWWn-1ud3mjr7sy4G83xIs_HnxB9kD2gFg4b3sO2YQfhiPMB7By--zCbbyw9ZOuJgvXduov3HnSNmZc9_2qbXQn3U9AF7-R_QqgHC13huGVtwou7GOmd4NUA1dEjeNgxTHLYduIxbNliF-5N-8Ruu3Bw3IarrkfkZON9VY3IATneBLKun8CPxjuXOqvzskBwIlVdIF-s8oroIiV58evnOl8tyxultSu43-P4YkvinCZcbgpSZqQo1_aC6GV94ZJW1wh2lpi8onlVXulv-MTPfCSo-bKolzniqaVzWl7lqa2ewunR25PpjHZpG2jChVrRUGpurM0UYzZVvkhwxccyM0lSlmYyY8JPkDZFaSoDY5WOlJXWJtIYZVhiQ8aewaDAbj0HoqLIhglP1MQovLcyoVY6c0HqmMxMkHhAe1HFizY6R9ybrZ3HrWhjJ9rYx8PnHqhenvGtWRYjgPyl5fCW-K8fhypPCCaYB6SfDzHK02276MKWl1WMBNTt1frKg712nmwah0wpEWHj_ZsT5_p6s2JlyCC4Q67Ig-Bfqk276O4uqsHqxX93-SXcd6XWTOkVDFbLS_saGdjKDGH7zfdg2H1nvwFqgjN3 |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9RAFB5qfaggRavWeKnzUPq042Yzt82jLJZV26XgFgoiw0wygZSaLEm6NH3wzf_hb_GXeSaX7hYqipCXSTKZzJzJ-b7JnAtC-zGgXsCoILHmY8LCsYFPSmiiQ8MDo0UoRs7f-Xgmpqfs4xk_20CT3hfGmVV2ur_V6Y227s4Mu9EcLtJ0-BnQB9gDaOGg4T30Hrrv2ICz63r7fc3OQ7R-KHC3W3Wx3n-uMfKy599ssyfhfgm60J3sT_j0cKFLGLWkTXdxFx-9E7oamDp8hLY7fonftV14jDZstoO2Jn1atx10cNIGq64HeL7yvSoH-ACfrMJY10_Qj8Y3lzib8zwDaMJlnQFbLNMS6yzGafbr5zKtinyttHQF93McXqzAzmXCZabAeYKzfGkvsC7qC5eyugaos9ikJUnL_EpfQ4tf2IAT83VRFymgqSUzkl-lsS2fotPD9_PJlHRJG0jEuKxIIDQz1iaSUhtLn0ew3qOJGUcxjRORUO5HQJrCOBYjY6UOpRXWRsIYaWhkA0qfoc0MuvUcYRmGNohYJMdGwrOlCbTUiQtRR0ViRpGHSC8qtWhjc6jeaO1ctaJVTrTKh8NnHpK9PNWtOaYAPv5Sc--W-G-aA4XHOeXUQ7ifDwrk6TZddGbzy1IB_XQ7tb700G47T1aVAyolD6Hy_vrEubnerFcp8AfmcCv00Ohfbpt0sd1dTIPqxX93-Q3ams6Pj9TRh9mnl-iBu9IaLL1Cm1VxaV8DF6vMXvOt_QY2PTRM |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Multi-component+synthesis+and+in%C2%A0vitro+and+in%C2%A0vivo+anticancer+activity+of+novel+arylmethylene+bis-isoxazolo%5B4%2C5-b%5Dpyridine-N-oxides&rft.jtitle=European+journal+of+medicinal+chemistry&rft.au=Rajanarendar%2C+E&rft.au=Raju%2C+S&rft.au=Reddy%2C+M+Nagi&rft.au=Krishna%2C+S+Rama&rft.date=2012-04-01&rft.eissn=1768-3254&rft.volume=50&rft.spage=274&rft.epage=279&rft_id=info:doi/10.1016%2Fj.ejmech.2012.02.004&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0223-5234&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0223-5234&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0223-5234&client=summon |