Functional Characterization of Polymorphisms in the Peptidase Inhibitor 3 (Elafin) Gene and Validation of Their Contribution to Risk of Acute Respiratory Distress Syndrome - Tejera, Paula; O’Mahony, D. Shane; Owen, Caroline A.; Wei, Yongyue; Wang, Zhaoxi; Gupta, Kushagra; Su, Li; Villar, Jesus; Wurfel, Mark; Christiani, David C. (American journal of respiratory cell and molecular biology, 2014)
Keywords: Adult; Aged; Binding Sites; Case-Control Studies; Cell Line, Tumor; Cytokines - metabolism; Deoxyribonucleic acid; DNA; Elafin - genetics; Elafin - metabolism; Female; Fibronectins - metabolism; Gene expression; Gene Expression Regulation; Gene Frequency; Genes, Reporter; Genetic Association Studies; Genetic Predisposition to Disease; Genetic testing; Haplotypes; Humans; Intensive care; Leukocyte Elastase - metabolism; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Original Research; Patients; Phenotype; Plasmids; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protein Binding; Proteins; Quality control; Respiratory distress syndrome; Respiratory Distress Syndrome, Adult - genetics; Respiratory Distress Syndrome, Adult - metabolism; Risk Factors; Rodents; Systemic Inflammatory Response Syndrome - genetics; Systemic Inflammatory Response Syndrome - metabolism; Transcription, Genetic; Transfection; Transglutaminases - metabolism; replication; acute respiratory distress syndrome; elafin; genetic association; single-nucleotide polymorphism