Modulating effects of Astragalus polysaccharide on immune disorders via gut microbiota and the TLR4/NF-κB pathway in rats with syndrome of dampness stagnancy due to spleen deficiency

• Published in: Journal of Zhejiang University. B. Science Vol. 24; no. 7; pp. 650 - 662
• Main Authors: Zhao, Wenxiao, Duan, Chenchen, Liu, Yanli, Lu, Guangying, Lyu, Qin, Liu, Xiumei, Zheng, Jun, Zhao, Xuelian, Wang, Shijun, Zhao, Haijun
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 01.07.2023; Springer Nature B.V; School of Nursing,Shandong University of Traditional Chinese Medicine,Jinan 250355,China%College of Traditional Chinese Medicine,Shandong Co-Innovation Center of Classic Traditional Chinese Medicine Formula,Shandong University of Traditional Chinese Medicine,Jinan 250355,China%School of Pharmaceutical Sciences,Cheeloo College of Medicine,Shandong University,Jinan 250012,China
• Subjects: Animals; Astragalus Plant - metabolism; Bacteria; Biomedical and Life Sciences; Biomedicine; Body Weight; Body weight gain; Correlation analysis; Discriminant analysis; Disorders; Endotoxins; Fatty acids; Gastrointestinal Microbiome; High fat diet; High protein diet; Immune System Diseases - drug therapy; Inflammation; Inflammatory response; Interleukin 6; Intestinal microflora; Low fat diet; Low protein diet; Microbiota; Microorganisms; Moisture content; Molecular weight; NF-kappa B - metabolism; NF-κB protein; Nutrient deficiency; Pathogenesis; Polysaccharides; Polysaccharides - pharmacology; Rats; Relative abundance; Research Article; Spleen; Swimming; TLR4 protein; Toll-Like Receptor 4; Toll-like receptors; Traditional Chinese medicine; Gut microbiota; Toll-like receptor 4/nuclear factor-κB (TLR4/NF-κB) pathway; 黄芪多糖; polysaccharide; Immune disorder; TLR4/NF-κB通路; 短链脂肪酸; Short-chain fatty acid; Dampness stagnancy due to spleen deficiency; 免疫功能紊乱; 肠道菌群; 脾虚水湿不化; Astragalus polysaccharide; Toll-like receptor 4/nuclear factor-κB(TLR4/NF-κB)pathway

The syndrome of dampness stagnancy due to spleen deficiency (DSSD) is relatively common globally. Although the pathogenesis of DSSD remains unclear, evidence has suggested that the gut microbiota might play a significant role. Radix Astragali , used as both medicine and food, exerts the effects of t...