Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine

• Published in: Dalton transactions : an international journal of inorganic chemistry no. 48; pp. 10690 - 10701
• Main Authors: Farrer, Nicola J., Salassa, Luca, Sadler, Peter J.
• Format: Journal Article
• Language: English
• Published: England 01.01.2009
• Subjects: Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Ligands; Metal Nanoparticles - chemistry; Metals - chemistry; Neoplasms - drug therapy; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Quantum Dots

The fields of phototherapy and of inorganic chemotherapy both have long histories. Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over drug activation and has remarkable potential for the treatment of cancer. Following photoexcitation, a number of different dec...