Location of inclusion cysts in mouse ovaries in relation to age, pregnancy, and total ovulation number: implications for ovarian cancer?
Benign ovarian cysts are thought to be precursor lesions that differentiate and transform into carcinoma. With the aim of testing the hypothesis that increased ovulation number increases the frequency or number of ovarian cysts, the development and appearance of ovarian cysts was investigated in mic...
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Published in | The Journal of pathology Vol. 205; no. 4; pp. 483 - 490 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.03.2005
Wiley |
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Abstract | Benign ovarian cysts are thought to be precursor lesions that differentiate and transform into carcinoma. With the aim of testing the hypothesis that increased ovulation number increases the frequency or number of ovarian cysts, the development and appearance of ovarian cysts was investigated in mice of differing ages and total lifetime ovulation number. High total ovulation number was induced by keeping mice in cages divided by a screen, with a male on one side and two females on the other side. Significantly more cysts were observed in animals subjected to incessant ovulation for 8 months and in 12 month breeding mice than in 3‐month virgin mice or 1‐month prepubertal animals. These cysts had the appearance of benign serous inclusion cysts. When cystic ovaries were serial sectioned, 47% of cysts had a connection to the ovarian hilus and potentially to the tubules of the rete ovarii, 31% were adjacent to the hilus, and 22% had an intra‐ovarian location. A significant increase in intra‐ovarian cysts was observed in the 8‐month incessant ovulation group, implying that high ovulation number leads to ovarian surface invagination and inclusion cyst formation. In conclusion, ovarian inclusion cysts may be derived from more than one epithelial source, but incessant ovulation may increase the proportion derived from the ovarian surface epithelium. Because the cysts observed resembled human serous inclusion cysts these results have possible implications for epithelial ovarian carcinoma. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
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AbstractList | Benign ovarian cysts are thought to be precursor lesions that differentiate and transform into carcinoma. With the aim of testing the hypothesis that increased ovulation number increases the frequency or number of ovarian cysts, the development and appearance of ovarian cysts was investigated in mice of differing ages and total lifetime ovulation number. High total ovulation number was induced by keeping mice in cages divided by a screen, with a male on one side and two females on the other side. Significantly more cysts were observed in animals subjected to incessant ovulation for 8 months and in 12 month breeding mice than in 3-month virgin mice or 1-month prepubertal animals. These cysts had the appearance of benign serous inclusion cysts. When cystic ovaries were serial sectioned, 47% of cysts had a connection to the ovarian hilus and potentially to the tubules of the rete ovarii, 31% were adjacent to the hilus, and 22% had an intra-ovarian location. A significant increase in intra-ovarian cysts was observed in the 8-month incessant ovulation group, implying that high ovulation number leads to ovarian surface invagination and inclusion cyst formation. In conclusion, ovarian inclusion cysts may be derived from more than one epithelial source, but incessant ovulation may increase the proportion derived from the ovarian surface epithelium. Because the cysts observed resembled human serous inclusion cysts these results have possible implications for epithelial ovarian carcinoma. Benign ovarian cysts are thought to be precursor lesions that differentiate and transform into carcinoma. With the aim of testing the hypothesis that increased ovulation number increases the frequency or number of ovarian cysts, the development and appearance of ovarian cysts was investigated in mice of differing ages and total lifetime ovulation number. High total ovulation number was induced by keeping mice in cages divided by a screen, with a male on one side and two females on the other side. Significantly more cysts were observed in animals subjected to incessant ovulation for 8 months and in 12 month breeding mice than in 3‐month virgin mice or 1‐month prepubertal animals. These cysts had the appearance of benign serous inclusion cysts. When cystic ovaries were serial sectioned, 47% of cysts had a connection to the ovarian hilus and potentially to the tubules of the rete ovarii, 31% were adjacent to the hilus, and 22% had an intra‐ovarian location. A significant increase in intra‐ovarian cysts was observed in the 8‐month incessant ovulation group, implying that high ovulation number leads to ovarian surface invagination and inclusion cyst formation. In conclusion, ovarian inclusion cysts may be derived from more than one epithelial source, but incessant ovulation may increase the proportion derived from the ovarian surface epithelium. Because the cysts observed resembled human serous inclusion cysts these results have possible implications for epithelial ovarian carcinoma. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
Author | Fleming, Jean. S. Tan, Olivia L. Hurst, Peter. R. |
Author_xml | – sequence: 1 givenname: Olivia L. surname: Tan fullname: Tan, Olivia L. organization: Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand – sequence: 2 givenname: Peter. R. surname: Hurst fullname: Hurst, Peter. R. organization: Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand – sequence: 3 givenname: Jean. S. surname: Fleming fullname: Fleming, Jean. S. email: jean.fleming@stonebow.otago.ac.nz organization: Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand |
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Keywords | Inclusion Ovary cancer Rodentia Malignant tumor inclusion cyst Ovulation ovarian surface epithelium Female genital diseases Pregnancy Ovarian diseases Vertebrata Anatomic pathology ovary Mammalia Number Mouse Animal Female genital system Cyst Female Benign neoplasm rete ovarii Age |
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Snippet | Benign ovarian cysts are thought to be precursor lesions that differentiate and transform into carcinoma. With the aim of testing the hypothesis that increased... |
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SubjectTerms | Aging - pathology Aging - physiology Animals Biological and medical sciences Cell Transformation, Neoplastic Epithelial Cells - chemistry Epithelial Cells - pathology Female Immunohistochemistry - methods Inclusion Bodies - pathology Inclusion Bodies - physiology inclusion cyst Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice mouse Ovarian Cysts - pathology Ovarian Cysts - physiopathology Ovarian Neoplasms - pathology Ovarian Neoplasms - physiopathology ovarian surface epithelium ovary Ovary - pathology Ovary - physiopathology ovulation Ovulation - physiology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Precancerous Conditions - pathology Precancerous Conditions - physiopathology Pregnancy Proliferating Cell Nuclear Antigen - analysis rete ovarii |
Title | Location of inclusion cysts in mouse ovaries in relation to age, pregnancy, and total ovulation number: implications for ovarian cancer? |
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