Pramipexole-induced somnolence and episodes of daytime sleep

• Published in: Movement disorders Vol. 15; no. 4; pp. 658 - 663
• Main Authors: Hauser, Robert A., Gauger, Lisa, Anderson, W. McDowell, Zesiewicz, Theresa A.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.07.2000; Wiley
• Subjects: Aged; Antiparkinson Agents - adverse effects; Antiparkinson Agents - therapeutic use; Automobile Driving; Benzothiazoles; Biological and medical sciences; Dose-Response Relationship, Drug; Double-Blind Method; Driving; Drug toxicity and drugs side effects treatment; Female; Humans; Levodopa - adverse effects; Levodopa - therapeutic use; Male; Medical sciences; Middle Aged; Narcolepsy - chemically induced; Narcolepsy - diagnosis; Parkinson Disease - drug therapy; Parkinson's disease; Pharmacology. Drug treatments; Polysomnography; Pramipexole; Retrospective Studies; Sleep; Somnolence; Thiazoles - adverse effects; Thiazoles - therapeutic use; Toxicity: nervous system and muscle; Human; Nervous system diseases; Agonist; Vehicle driving; Toxicity; Parkinson disease; Pramipexole; Cerebral disorder; Somnolence; D2 Dopamine receptor; Central nervous system disease; Degenerative disease; Extrapyramidal syndrome

Pramipexole is a non‐ergot dopamine agonist used to treat Parkinson's disease (PD). Because of concern regarding driving safety, we evaluated the incidence and nature of somnolence experienced by patients receiving pramipexole in clinical trials at our center. A retrospective chart review was p...