Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro

• Published in: Annals of neurology Vol. 64; no. 6; pp. 674 - 686
• Main Authors: Gnatkovsky, Vadym, Librizzi, Laura, Trombin, Federica, de Curtis, Marco
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2008; Wiley-Liss
• Subjects: Action Potentials - physiology; Animals; Biological and medical sciences; Entorhinal Cortex - physiology; Guinea Pigs; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; In Vitro Techniques; Inhibitory Postsynaptic Potentials - physiology; Medical sciences; Nerve Net - physiology; Nervous system (semeiology, syndromes); Neural Inhibition - physiology; Neurology; Seizures - physiopathology; Nervous system diseases; Convulsion; Entorhinal cortex; Epilepsy; Central nervous system disease; Central nervous system; Neurological disorder; Encephalon; Cerebral disorder

Objective Network mechanisms responsible for focal seizure initiation are still largely unknown. One of the prevalent seizure patterns observed during diagnostic intracranial recordings performed in patients with mesial temporal lobe epilepsy is characterized by fast activity at 20 to 30Hz. We repro...