Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats

• Published in: Anesthesia and analgesia Vol. 129; no. 5; pp. 1365 - 1373
• Main Authors: Chinn, Gregory A, Sasaki Russell, Jennifer M, Banh, Esther T, Lee, Saehee C, Sall, Jeffrey W
• Format: Journal Article
• Language: English
• Published: United States International Anesthesia Research Society 01.11.2019
• Subjects: Anesthetics, Inhalation - toxicity; Animals; Brain-Derived Neurotrophic Factor - genetics; Hippocampus - pathology; Isoflurane - toxicity; Male; Maze Learning - drug effects; Memory Disorders - prevention & control; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Spatial Memory - drug effects

BACKGROUND:Early life anesthesia exposure results in long-term cognitive deficits in rats. Environmental enrichment consisting of social housing, a stimulating environment, and voluntary exercise can rescue this deficit. We hypothesized that exercise alone is sufficient to rescue the cognitive defic...