A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: The Treatment of Early Aggressive Rheumatoid Arthritis trial

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 64; no. 9; pp. 2824 - 2835
• Main Authors: Moreland, Larry W., O'Dell, James R., Paulus, Harold E., Curtis, Jeffrey R., Bathon, Joan M., St.Clair, E. William, Bridges Jr, S. Louis, Zhang, Jie, McVie, Theresa, Howard, George, van der Heijde, Désirée, Cofield, Stacey S.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2012; Wiley Subscription Services, Inc
• Subjects: Administration, Oral; Adult; Aged; Antirheumatic Agents - administration & dosage; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - diagnostic imaging; Arthritis, Rheumatoid - drug therapy; Blood Sedimentation; Double-Blind Method; Drug Administration Schedule; Drug therapy; Drug Therapy, Combination; Etanercept; Female; HIV; Human immunodeficiency virus; Humans; Hydroxychloroquine - administration & dosage; Immunoglobulin G - administration & dosage; Immunoglobulin G - therapeutic use; Male; Methotrexate; Methotrexate - administration & dosage; Methotrexate - therapeutic use; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor - administration & dosage; Receptors, Tumor Necrosis Factor - therapeutic use; Rheumatoid arthritis; Severity of Illness Index; Sulfasalazine - administration & dosage; Treatment Outcome

Objective To assess whether it is better to intensively treat all patients with early rheumatoid arthritis (RA) using combinations of drugs or to reserve this approach for patients who do not have an appropriate response (as determined by a Disease Activity Score in 28 joints using the erythrocyte s...