Hepatocyte growth factor (HGF) and the satellite cell response following muscle lengthening contractions in humans

• Published in: Muscle & nerve Vol. 38; no. 5; pp. 1434 - 1442
• Main Authors: O'Reilly, Ciara, McKay, Bryon, Phillips, Stuart, Tarnopolsky, Mark, Parise, Gianni
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2008; Wiley
• Subjects: Adolescent; Analysis of Variance; Biological and medical sciences; Enzyme-Linked Immunosorbent Assay - methods; exercise; Exercise - physiology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - physiology; hepatocyte growth factor; Hepatocyte Growth Factor - blood; human muscle repair; Humans; Laminin - metabolism; Male; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Muscle Contraction - physiology; Muscle, Skeletal - cytology; Muscle, Skeletal - physiology; Neural Cell Adhesion Molecules - metabolism; Proteinase Inhibitory Proteins, Secretory - metabolism; satellite cells; Satellite Cells, Skeletal Muscle - metabolism; Satellite Cells, Skeletal Muscle - physiology; Serine Endopeptidases - metabolism; Striated muscle. Tendons; Time Factors; Vertebrates: nervous system and sense organs; Vertebrates: osteoarticular system, musculoskeletal system; Young Adult; Human; Cell contraction; Quadriceps femoris muscle; Lower limb; exercise; human muscle repair; Striated muscle; Muscle contraction; Protein; Rest; Actin; Biopsy; hepatocyte growth factor; Serum; Repair; satellite cells

The time‐courses of satellite cell (SC) activation and protein expression of hepatocyte growth factor (HGF), HGF activator (HGFA), HGFA inhibitor‐1 (HAI‐1), and HGFA inhibitor‐2 (HAI‐2) in human skeletal muscle, as well as serum HGF following a single bout of muscle lengthening contractions, were de...