Increased risk of hospitalization for acute hepatitis in patients with previous exposure to NSAIDs

• Published in: Pharmacoepidemiology and drug safety Vol. 19; no. 7; pp. 708 - 714
• Main Authors: Lee, Chang-Hsing, Wang, Jung-Der, Chen, Pau-Chung
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2010
• Subjects: Acute Disease; acute hepatitis; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; case-crossover design; Celecoxib; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - etiology; cyclooxygenase 2 inhibitors; Databases, Factual; Female; Hospitalization - statistics & numerical data; Humans; Logistic Models; Male; Middle Aged; non-steroidal anti-inflammatory drugs; Pyrazoles - adverse effects; Risk; Sulfonamides - adverse effects; Taiwan - epidemiology; Young Adult; Taiwan

Background Epidemiological studies related to hospitalization due to the hepatotoxicity of traditional non‐steroidal anti‐inflammatory drugs (NSAIDs) are infrequent, and case reports of hepatotoxicity of nimesulide, celecoxib, and rofecoxib seem to be increasing. The reimbursement database of Nation...