Analysis of Hepatitis B Virus Haplotype Diversity Detects Striking Sequence Conservation Across Genotypes and Chronic Disease Phase

• Published in: Hepatology (Baltimore, Md.) Vol. 73; no. 5; pp. 1652 - 1670
• Main Authors: Wagner, Josef, Yuen, Lilly, Littlejohn, Margaret, Sozzi, Vitina, Jackson, Kathy, Suri, Vithika, Tan, Susanna, Feierbach, Becket, Gaggar, Anuj, Marcellin, Patrick, Buti Ferret, Maria, Janssen, Harry L.A., Gane, Ed, Chan, Henry L.Y., Colledge, Danni, Rosenberg, Gillian, Bayliss, Julianne, Howden, Benjamin P, Locarnini, Stephen A., Wong, Darren, Thompson, Alexander T., Revill, Peter A.
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.05.2021
• Subjects: Adolescent; Adult; Antiretroviral drugs; Antiviral agents; Antiviral drugs; Chronic illnesses; Chronic infection; Conserved sequence; Conserved Sequence - genetics; Disease Progression; Female; Genetic diversity; Genetic Variation - genetics; Genome, Viral - genetics; Genomes; Genotype; Genotypes; Haplotypes; Haplotypes - genetics; Hepatitis B; Hepatitis B e antigen; Hepatitis B e Antigens - genetics; Hepatitis B virus - genetics; Hepatitis B, Chronic - pathology; Hepatitis B, Chronic - virology; Hepatology; Humans; Male; Middle Aged; Nucleotides; Regulatory sequences; Sequence Analysis, DNA; Tenofovir; Young Adult

Background and Aims We conducted haplotype analysis of complete hepatitis B virus (HBV) genomes following deep sequencing from 368 patients across multiple phases of chronic hepatitis B (CHB) infection from four major genotypes (A‐D), analyzing 4,110 haplotypes to identify viral variants associated...