Disconnecting Consciousness: Is There a Common Anesthetic End Point?

• Published in: Anesthesia and analgesia Vol. 123; no. 5; pp. 1228 - 1240
• Main Authors: Hudetz, Anthony G., Mashour, George A.
• Format: Journal Article
• Language: English
• Published: United States International Anesthesia Research Society 01.11.2016
• Subjects: Anesthesia - methods; Anesthetics - administration & dosage; Brain - drug effects; Brain - physiology; Consciousness - drug effects; Consciousness - physiology; Electroencephalography - drug effects; Electroencephalography - methods; Humans; Nerve Net - drug effects; Nerve Net - physiology

A quest for a systems-level neuroscientific basis of anesthetic-induced loss and return of consciousness has been in the forefront of research for the past 2 decades. Recent advances toward the discovery of underlying mechanisms have been achieved using experimental electrophysiology, multichannel e...