Increased permeability of the epithelium of middle ear cholesteatoma

• Published in: Clinical otolaryngology Vol. 40; no. 2; pp. 106 - 114
• Main Authors: Koizumi, H., Suzuki, H., Ohbuchi, T., Kitamura, T., Hashida, K., Nakamura, M.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2015; Wiley Subscription Services, Inc
• Subjects: Bone Resorption; Case-Control Studies; Cholesteatoma, Middle Ear - metabolism; Cholesteatoma, Middle Ear - pathology; Cholesteatoma, Middle Ear - surgery; Claudin-1 - genetics; Claudin-1 - metabolism; Claudin-3 - genetics; Claudin-3 - metabolism; Electric Impedance; Epithelium - metabolism; Humans; MARVEL Domain Containing 2 Protein - genetics; MARVEL Domain Containing 2 Protein - metabolism; Permeability; RNA, Messenger - metabolism

Objective We investigated the electrical impedance of and the expressions of tight junction molecules in the cholesteatoma epithelium to provide supporting evidence for the acid lysis theory of bone resorption in middle ear cholesteatoma. Methods Study subjects were patients with primary acquired mi...