The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: Possible role of HBx in invasion and metastasis

• Published in: Hepatology (Baltimore, Md.) Vol. 33; no. 5; pp. 1270 - 1281
• Main Authors: Lara-Pezzi, Enrique, Serrador, Juan M., Montoya, Marı́a C., Zamora, David, Yáñez-Mó, Marı́a, Carretero, Marta, Furthmayr, Heinz, Sánchez-Madrid, Francisco, López-Cabrera, Manuel
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01.05.2001; W.B. Saunders; Wiley
• Subjects: Actins - metabolism; Adaptor Proteins, Signal Transducing; Biological and medical sciences; Carrier Proteins - metabolism; Carrier Proteins - pharmacology; Carrier Proteins - physiology; Cell Adhesion Molecules - metabolism; Cell Membrane - metabolism; Cell Movement - drug effects; Cell Movement - physiology; Cell Polarity - physiology; Cytoskeleton - ultrastructure; Gastroenterology. Liver. Pancreas. Abdomen; HeLa Cells - cytology; HeLa Cells - ultrastructure; Humans; Hyaluronan Receptors - physiology; Hyaluronic Acid - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Neoplasm Invasiveness - physiopathology; Neoplasm Metastasis - physiopathology; Phenotype; Pseudopodia - metabolism; rho GTP-Binding Proteins - physiology; Tissue Distribution - drug effects; Tumors; Viral Nonstructural Proteins - pharmacology; Viral Nonstructural Proteins - physiology; Human; Pathogenesis; Migration; Hepatic disease; Hepatocellular carcinoma; Malignant tumor; Metastasis; Experimental study; Infection; Viral hepatitis B; Cell line; Viral disease; Digestive diseases; Complication; Mechanism of action; Tumor cell

The hepatitis B virus X protein (HBx) of the hepatitis B virus (HBV) has been involved in the development of hepatocellular carcinoma (HCC). However, its possible contribution to the metastatic spreading of liver tumors has not been explored so far. We report here the ability of HBx to enhance cell...