Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects

• Published in: Journal of clinical pharmacology Vol. 58; no. 11; p. 1427
• Main Authors: Liu, Lichuan, Cheeti, Sravanthi, Yoshida, Kenta, Choo, Edna, Chen, Eugene, Chen, Buyun, Gates, Mary, Singel, Stina, Morley, Roland, Ware, Joseph, Sahasranaman, Srikumar
• Format: Journal Article
• Language: English
• Published: England 01.11.2018
• Subjects: OATP; endogenous biomarker; statin; coproporphyrin I and III; drug-drug interaction

Developed as an oral anticancer drug to treat estrogen receptor-positive breast cancer, GDC-0810 was shown to be a potent inhibitor of organic anion-transporting polypeptide 1B1 and 1B3 (OATP1B1/1B3) from an in vitro assay. A clinical study was conducted to assess the drug-drug interaction potential...