Amsacrine suppresses matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia cells

• Published in: Journal of cellular physiology Vol. 229; no. 5; pp. 588 - 598
• Main Authors: Liu, Wen-Hsin, Chen, Ying-Jung, Chien, Jen-Hung, Chang, Long-Sen
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2014; Wiley Subscription Services, Inc
• Subjects: Amsacrine - chemistry; Amsacrine - pharmacology; Decay; Down-Regulation; Enzyme Inhibitors - pharmacology; Gene Expression Regulation, Neoplastic; Humans; Inactivation; Leukemia; Leukemia - enzymology; MAP Kinase Kinase 4 - genetics; MAP Kinase Kinase 4 - metabolism; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Molecular Structure; p38 Mitogen-Activated Protein Kinases - genetics; p38 Mitogen-Activated Protein Kinases - metabolism; Protein Phosphatase 2 - classification; Protein Phosphatase 2 - genetics; Protein Phosphatase 2 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; U937 Cells; Up-Regulation

This study explores the suppression mechanism of amsacrine (4‐(9‐Acridinylamino)‐N‐(methanesulfonyl)‐m‐anisidine hydrochloride) on matrix metalloproteinase‐2 (MMP‐2) and MMP‐9 expression in human leukemia cells. Amsacrine attenuated cell invasion with decreased MMP‐2/MMP‐9 protein expression and mRN...