The mechanism underlying the effects of the cell surface ATP synthase on the regulation of intracellular acidification during acidosis

• Published in: Journal of cellular biochemistry Vol. 114; no. 7; pp. 1695 - 1703
• Main Authors: Wang, Wen-juan, Shi, Xiao-xing, Liu, Yi-wen, He, Yi-qing, Wang, Ying-zhi, Yang, Cui-xia, Gao, Feng
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2013; Wiley Subscription Services, Inc
• Subjects: Acidification; Acidosis - enzymology; Acidosis - metabolism; Adenosine Triphosphatases - metabolism; Animals; APOPTOSIS; Apoptosis - physiology; ATP; Blotting, Western; Cell Line; Cell Proliferation; CELL SURFACE ATP SYNTHASE; CHO Cells; Cricetinae; Cricetulus; Fluorescent Antibody Technique; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Hypertension; Inhibitors; INTRACELLULAR ACIDIFICATION; Microscopy, Confocal; PC12 Cells; PROLIFERATION; Rats; TUMOR

The F1F0 ATP synthase has recently become the focus of anti‐cancer research. It was once thought that ATP synthases were located strictly on the inner mitochondrial membrane; however, in 1994, it was found that some ATP synthases localized to the cell surface. The cell surface ATP synthases are invo...