Structure–Activity Relationship of Terpenes with Anti‐Inflammatory Profile – A Systematic Review

Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for th...

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Published in	Basic & clinical pharmacology & toxicology Vol. 115; no. 3; pp. 244 - 256
Main Authors	Santana Souza, Marilia Trindade, Almeida, Jackson Roberto Guedes da Silva, Souza Araujo, Adriano Antunes, Duarte, Marcelo Cavalcante, Gelain, Daniel Pens, Moreira, José Cláudio Fonseca, Santos, Marcio Roberto Viana, Quintans‐Júnior, Lucindo José
Format	Journal Article
Language	English
Published	Oxford Blackwell 01.09.2014 Wiley Subscription Services, Inc
Subjects	Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Databases, Factual Disease Models, Animal Drug therapy Humans Inflammation - drug therapy Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Terpenes - chemistry Terpenes - pharmacology Systematic review Terpene Review Structure activity relation Antiinflammatory agent
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Abstract	Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for the development of anti‐inflammatory drugs, once their chemical diversity is well suited to provide skeleton for future anti‐inflammatory drugs. This systematic review reports the studies present in the literature that evaluate the anti‐inflammatory activity of terpenes suffering any change in their structures, assessing whether these changes also brought changes in their effects. The search terms anti‐inflammatory agents, terpenes, and structure–activity relationship were used to retrieve English language articles in SCOPUS, PUBMED and EMBASE published between January 2002 and August 2013. Twenty‐seven papers were found concerning the structural modification of terpenes with the evaluation of anti‐inflammatory activity. The data reviewed here suggest that modified terpenes are an interesting tool for the development of new anti‐inflammatory drugs.
AbstractList	Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for the development of anti-inflammatory drugs, once their chemical diversity is well suited to provide skeleton for future anti-inflammatory drugs. This systematic review reports the studies present in the literature that evaluate the anti-inflammatory activity of terpenes suffering any change in their structures, assessing whether these changes also brought changes in their effects. The search terms anti-inflammatory agents, terpenes, and structure–activity relationship were used to retrieve English language articles in SCOPUS, PUBMED and EMBASE published between January 2002 and August 2013. Twenty-seven papers were found concerning the structural modification of terpenes with the evaluation of antiinflammatory activity. The data reviewed here suggest that modified terpenes are an interesting tool for the development of new anti-inflammatory drugs. Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for the development of anti‐inflammatory drugs, once their chemical diversity is well suited to provide skeleton for future anti‐inflammatory drugs. This systematic review reports the studies present in the literature that evaluate the anti‐inflammatory activity of terpenes suffering any change in their structures, assessing whether these changes also brought changes in their effects. The search terms anti‐inflammatory agents, terpenes, and structure–activity relationship were used to retrieve English language articles in SCOPUS, PUBMED and EMBASE published between January 2002 and August 2013. Twenty‐seven papers were found concerning the structural modification of terpenes with the evaluation of anti‐inflammatory activity. The data reviewed here suggest that modified terpenes are an interesting tool for the development of new anti‐inflammatory drugs. Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for the development of anti-inflammatory drugs, once their chemical diversity is well suited to provide skeleton for future anti-inflammatory drugs. This systematic review reports the studies present in the literature that evaluate the anti-inflammatory activity of terpenes suffering any change in their structures, assessing whether these changes also brought changes in their effects. The search terms anti-inflammatory agents, terpenes, and structure-activity relationship were used to retrieve English language articles in SCOPUS,PUBMED and EMBASE published between January 2002 and August 2013. Twenty-seven papers were found concerning the structural modification of terpenes with the evaluation of anti-inflammatory activity. The data reviewed here suggest that modified terpenes are an interesting tool for the development of new anti-inflammatory drugs. [PUBLICATION ABSTRACT] Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for the development of anti-inflammatory drugs, once their chemical diversity is well suited to provide skeleton for future anti-inflammatory drugs. This systematic review reports the studies present in the literature that evaluate the anti-inflammatory activity of terpenes suffering any change in their structures, assessing whether these changes also brought changes in their effects. The search terms anti-inflammatory agents, terpenes, and structure–activity relationship were used to retrieve English language articles in SCOPUS, PUBMED and EMBASE published between January 2002 and August 2013. Twenty-seven papers were found concerning the structural modification of terpenes with the evaluation of antiinflammatory activity. The data reviewed here suggest that modified terpenes are an interesting tool for the development of new anti-inflammatory drugs.Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for the development of anti-inflammatory drugs, once their chemical diversity is well suited to provide skeleton for future anti-inflammatory drugs. This systematic review reports the studies present in the literature that evaluate the anti-inflammatory activity of terpenes suffering any change in their structures, assessing whether these changes also brought changes in their effects. The search terms anti-inflammatory agents, terpenes, and structure–activity relationship were used to retrieve English language articles in SCOPUS, PUBMED and EMBASE published between January 2002 and August 2013. Twenty-seven papers were found concerning the structural modification of terpenes with the evaluation of antiinflammatory activity. The data reviewed here suggest that modified terpenes are an interesting tool for the development of new anti-inflammatory drugs.
Author	Almeida, Jackson Roberto Guedes da Silva Santos, Marcio Roberto Viana Santana Souza, Marilia Trindade Moreira, José Cláudio Fonseca Souza Araujo, Adriano Antunes Duarte, Marcelo Cavalcante Quintans‐Júnior, Lucindo José Gelain, Daniel Pens
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Snippet	Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural...
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SubjectTerms	Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Databases, Factual Disease Models, Animal Drug therapy Humans Inflammation - drug therapy Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Terpenes - chemistry Terpenes - pharmacology
Title	Structure–Activity Relationship of Terpenes with Anti‐Inflammatory Profile – A Systematic Review
URI	https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbcpt.12221 https://www.ncbi.nlm.nih.gov/pubmed/25275147 https://www.proquest.com/docview/1553285937 https://www.proquest.com/docview/1586096817
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