Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study

• Published in: Stem cells (Dayton, Ohio) Vol. 30; no. 6; pp. 1277 - 1285
• Main Authors: Blanquer, Miguel, Moraleda, Jose M., Iniesta, Francisca, Gómez-Espuch, Joaquín, Meca-Lallana, José, Villaverde, Ramón, Pérez-Espejo, Miguel Ángel, Ruíz-López, Francisco José, García Santos, José María, Bleda, Patricia, Izura, Virginia, Sáez, María, De Mingo, Pedro, Vivancos, Laura, Carles, Rafael, Jiménez, Judith, Hernández, Joaquín, Guardiola, Julia, Del Rio, Silvia Torres, Antúnez, Carmen, De La Rosa, Pedro, Majado, Maria Juliana, Sánchez-Salinas, Andrés, López, Javier, Martínez-Lage, Juan Francisco, Martínez, Salvador
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2012; Oxford University Press
• Subjects: Adult; Adult stem cells; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - pathology; Amyotrophic Lateral Sclerosis - surgery; Bone marrow; Bone Marrow Cells - pathology; Bone Marrow Transplantation - methods; Clinical trials; Female; Humans; Male; Middle Aged; Motor Neurons - pathology; Nerve Degeneration - pathology; Pilot Projects; Somatic cell therapy; Spinal Cord - pathology; Spinal Cord - surgery; Stem cell transplantation

The objective of this article is to assess the safety of intraspinal infusion of autologous bone marrow mononuclear cells (BMNCs) and, ultimately, to look for histopathological signs of cellular neurotrophism in amyotrophic lateral sclerosis (ALS) patients. We conducted an open single arm phase I tr...