Direct profiling of phospholipids and lysophospholipids in rat brain sections after ischemic stroke

• Published in: Rapid communications in mass spectrometry Vol. 24; no. 14; pp. 2057 - 2064
• Main Authors: Wang, Hay-Yan J., Liu, Cheng Bin, Wu, Hsuan-Wen, Kuo, Jr Shin
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 30.07.2010
• Subjects: Adducts; Alkalis; Animals; Brain - metabolism; Brain Chemistry; Brain injury; Brain Ischemia - complications; Cerebral blood flow; Cerebral infarction; Cortex; Disease Models, Animal; Heme; Humans; Inflammation; Ischemia; Lasers; Lecithin; Lipids; Lysophosphatidylcholine; Lysophospholipids - analysis; Lysophospholipids - metabolism; Male; Mass spectroscopy; Metabolism; Metals; Phospholipids; Phospholipids - analysis; Phospholipids - metabolism; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; sphingomyelin; Stroke; Stroke - etiology; Stroke - metabolism

Stroke, a deleterious cerebrovascular event, is caused by a critical reduction in the blood flow to the brain parenchyma that leads to brain injury and loss of brain functions. The inflammatory responses following ischemia often aggravate the neurological damage. Several pro‐inflammatory mediators r...