Regulation of lipid peroxidation and ferroptosis in diverse species

• Published in: Genes & development Vol. 32; no. 9-10; pp. 602 - 619
• Main Authors: Conrad, Marcus, Kagan, Valerian E., Bayir, Hülya, Pagnussat, Gabriela C., Head, Brian, Traber, Maret G., Stockwell, Brent R.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.05.2018
• Subjects: Animals; Antioxidants - metabolism; Biological Evolution; Cell Death - physiology; Humans; Iron - metabolism; Lipid Peroxidation; Reactive Oxygen Species - metabolism; Review; Species Specificity; iron; ferroptosis; cell death; lipid peroxidation; ROS; vitamin E

Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q 10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione a...