Controlling organoid symmetry breaking uncovers an excitable system underlying human axial elongation

• Published in: Cell Vol. 186; no. 3; pp. 497 - 512.e23
• Main Authors: Anand, Giridhar M., Megale, Heitor C., Murphy, Sean H., Weis, Theresa, Lin, Zuwan, He, Yichun, Wang, Xiao, Liu, Jia, Ramanathan, Sharad
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.02.2023
• Subjects: axial elongation; bioengineering; Body Patterning; Embryo, Mammalian; human stem cell models; Humans; Mesoderm; Organoids; reproducible; statistical inference; Wnt Signaling Pathway; statistical inference; axial elongation; reproducible; human stem cell models; bioengineering

The human embryo breaks symmetry to form the anterior-posterior axis of the body. As the embryo elongates along this axis, progenitors in the tail bud give rise to tissues that generate spinal cord, skeleton, and musculature. This raises the question of how the embryo achieves axial elongation and p...