Engineered protein-iron oxide hybrid biomaterial for MRI-traceable drug encapsulation
Labeled protein-based biomaterials have become popular for various biomedical applications such as tissue-engineered, therapeutic, and diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, has enabled a wide variety of i...
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Published in | Molecular systems design & engineering Vol. 7; no. 8; pp. 915 - 932 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
01.08.2022
Royal Society of Chemistry (RSC) |
Subjects | |
Online Access | Get full text |
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Abstract | Labeled protein-based biomaterials have become popular for various biomedical applications such as tissue-engineered, therapeutic, and diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, has enabled a wide variety of imaging and therapeutic techniques. These USPIO-based biomaterials are widely studied in magnetic resonance imaging (MRI), thermotherapy, and magnetically-driven drug delivery, which provide a method for direct and non-invasive monitoring of implants or drug delivery agents. Where most developments have been made using polymers or collagen hydrogels, shown here is the use of a rationally designed protein as the building block for a meso-scale fiber. While USPIOs have been chemically conjugated to antibodies, glycoproteins, and tissue-engineered scaffolds for targeting or improved biocompatibility and stability, these constructs have predominantly served as diagnostic agents and often involve harsh conditions for USPIO synthesis. Here, we present an engineered protein-iron oxide hybrid material comprised of an azide-functionalized coiled-coil protein with small molecule binding capacity conjugated
via
bioorthogonal azide-alkyne cycloaddition to an alkyne-bearing iron oxide templating peptide, CMms6, for USPIO biomineralization under mild conditions. The coiled-coil protein, dubbed Q, has been previously shown to form nanofibers and, upon small molecule binding, further assembles into mesofibers
via
encapsulation and aggregation. The resulting hybrid material is capable of doxorubicin encapsulation as well as sensitive
-weighted MRI darkening for strong imaging capability that is uniquely derived from a coiled-coil protein.
This protein-iron oxide hybrid biomaterial aims to integrate the drug encapsulating potential of a coiled-coil protein with peptide-driven iron oxide biomineralization to serve as drug-carrying, MRI-detectable mesofiber. |
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AbstractList | Labeled protein-based biomaterials have become a popular for various biomedical applications such as tissue-engineered, therapeutic, or diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall super-paramagnetic iron oxide (USPIO) nanoparticles, has enabled a wide variety of imaging techniques. These USPIO-based biomaterials are widely studied in magnetic resonance imaging (MRI), thermotherapy, and magnetically-driven drug delivery which provide a method for direct and non-invasive monitoring of implants or drug delivery agents. Where most developments have been made using polymers or collagen hydrogels, shown here is the use of a rationally designed protein as the building block for a meso-scale fiber. While USPIOs have been chemically conjugated to antibodies, glycoproteins, and tissue-engineered scaffolds for targeting or improved biocompatibility and stability, these constructs have predominantly served as diagnostic agents and often involve harsh conditions for USPIO synthesis. Here, we present an engineered protein-iron oxide hybrid material comprised of an azide-functionalized coiled-coil protein with small molecule binding capacity conjugated via bioorthogonal azide-alkyne cycloaddition to an alkyne-bearing iron oxide templating peptide, CMms6, for USPIO biomineralization under mild conditions. The coiled-coil protein, dubbed Q, has been previously shown to form nanofibers and, upon small molecule binding, further assembles into mesofibers via encapsulation and aggregation. The resulting hybrid material is capable of doxorubicin encapsulation as well as sensitive
T
2
*-weighted MRI darkening for strong imaging capability that is uniquely derived from a coiled-coil protein. Labeled protein-based biomaterials have become popular for various biomedical applications such as tissue-engineered, therapeutic, and diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, has enabled a wide variety of imaging and therapeutic techniques. These USPIO-based biomaterials are widely studied in magnetic resonance imaging (MRI), thermotherapy, and magnetically-driven drug delivery, which provide a method for direct and non-invasive monitoring of implants or drug delivery agents. Where most developments have been made using polymers or collagen hydrogels, shown here is the use of a rationally designed protein as the building block for a meso-scale fiber. While USPIOs have been chemically conjugated to antibodies, glycoproteins, and tissue-engineered scaffolds for targeting or improved biocompatibility and stability, these constructs have predominantly served as diagnostic agents and often involve harsh conditions for USPIO synthesis. Here, we present an engineered protein–iron oxide hybrid material comprised of an azide-functionalized coiled-coil protein with small molecule binding capacity conjugated via bioorthogonal azide–alkyne cycloaddition to an alkyne-bearing iron oxide templating peptide, CMms6, for USPIO biomineralization under mild conditions. The coiled-coil protein, dubbed Q, has been previously shown to form nanofibers and, upon small molecule binding, further assembles into mesofibers via encapsulation and aggregation. The resulting hybrid material is capable of doxorubicin encapsulation as well as sensitive -weighted MRI darkening for strong imaging capability that is uniquely derived from a coiled-coil protein. Labeled protein-based biomaterials have become popular for various biomedical applications such as tissue-engineered, therapeutic, and diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, has enabled a wide variety of imaging and therapeutic techniques. These USPIO-based biomaterials are widely studied in magnetic resonance imaging (MRI), thermotherapy, and magnetically-driven drug delivery, which provide a method for direct and non-invasive monitoring of implants or drug delivery agents. Where most developments have been made using polymers or collagen hydrogels, shown here is the use of a rationally designed protein as the building block for a meso-scale fiber. While USPIOs have been chemically conjugated to antibodies, glycoproteins, and tissue-engineered scaffolds for targeting or improved biocompatibility and stability, these constructs have predominantly served as diagnostic agents and often involve harsh conditions for USPIO synthesis. Here, we present an engineered protein–iron oxide hybrid material comprised of an azide-functionalized coiled-coil protein with small molecule binding capacity conjugated via bioorthogonal azide–alkyne cycloaddition to an alkyne-bearing iron oxide templating peptide, CMms6, for USPIO biomineralization under mild conditions. The coiled-coil protein, dubbed Q, has been previously shown to form nanofibers and, upon small molecule binding, further assembles into mesofibers via encapsulation and aggregation. The resulting hybrid material is capable of doxorubicin encapsulation as well as sensitive [Formula Omitted]-weighted MRI darkening for strong imaging capability that is uniquely derived from a coiled-coil protein. This protein–iron oxide hybrid biomaterial aims to integrate the drug encapsulating potential of a coiled-coil protein with peptide-driven iron oxide biomineralization to serve as drug-carrying, MRI-detectable mesofiber. Labeled protein-based biomaterials have become popular for various biomedical applications such as tissue-engineered, therapeutic, and diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, has enabled a wide variety of imaging and therapeutic techniques. These USPIO-based biomaterials are widely studied in magnetic resonance imaging (MRI), thermotherapy, and magnetically-driven drug delivery, which provide a method for direct and non-invasive monitoring of implants or drug delivery agents. Where most developments have been made using polymers or collagen hydrogels, shown here is the use of a rationally designed protein as the building block for a meso-scale fiber. While USPIOs have been chemically conjugated to antibodies, glycoproteins, and tissue-engineered scaffolds for targeting or improved biocompatibility and stability, these constructs have predominantly served as diagnostic agents and often involve harsh conditions for USPIO synthesis. Here, we present an engineered protein-iron oxide hybrid material comprised of an azide-functionalized coiled-coil protein with small molecule binding capacity conjugated via bioorthogonal azide-alkyne cycloaddition to an alkyne-bearing iron oxide templating peptide, CMms6, for USPIO biomineralization under mild conditions. The coiled-coil protein, dubbed Q, has been previously shown to form nanofibers and, upon small molecule binding, further assembles into mesofibers via encapsulation and aggregation. The resulting hybrid material is capable of doxorubicin encapsulation as well as sensitive -weighted MRI darkening for strong imaging capability that is uniquely derived from a coiled-coil protein. This protein-iron oxide hybrid biomaterial aims to integrate the drug encapsulating potential of a coiled-coil protein with peptide-driven iron oxide biomineralization to serve as drug-carrying, MRI-detectable mesofiber. Labeled protein-based biomaterials have become a popular for various biomedical applications such as tissue-engineered, therapeutic, or diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall super-paramagnetic iron oxide (USPIO) nanoparticles, has enabled a wide variety of imaging techniques. These USPIO-based biomaterials are widely studied in magnetic resonance imaging (MRI), thermotherapy, and magnetically-driven drug delivery which provide a method for direct and non-invasive monitoring of implants or drug delivery agents. Where most developments have been made using polymers or collagen hydrogels, shown here is the use of a rationally designed protein as the building block for a meso-scale fiber. While USPIOs have been chemically conjugated to antibodies, glycoproteins, and tissue-engineered scaffolds for targeting or improved biocompatibility and stability, these constructs have predominantly served as diagnostic agents and often involve harsh conditions for USPIO synthesis. Here, we present an engineered protein-iron oxide hybrid material comprised of an azide-functionalized coiled-coil protein with small molecule binding capacity conjugated via bioorthogonal azide-alkyne cycloaddition to an alkyne-bearing iron oxide templating peptide, CMms6, for USPIO biomineralization under mild conditions. The coiled-coil protein, dubbed Q, has been previously shown to form nanofibers and, upon small molecule binding, further assembles into mesofibers via encapsulation and aggregation. The resulting hybrid material is capable of doxorubicin encapsulation as well as sensitive *-weighted MRI darkening for strong imaging capability that is uniquely derived from a coiled-coil protein. |
Author | Bonneau, Richard Montclare, Jin Kim Xie, Xuan Delgado-Fukushima, Erika Wadghiri, Youssef Z Hill, Lindsay K Punia, Kamia Jihad, Teeba Liu, Che Fu Liu, Chengliang Hu, Chunhua Meleties, Michael Renfrew, P. Douglas Britton, Dustin Mishkit, Orin |
AuthorAffiliation | Simons Foundation Computer Science Department Tandon School of Engineering Center for Advanced Imaging Innovation and Research (CAI Department of Chemical and Biomolecular Engineering Courant Institute of Mathematical Sciences Department of Biomedical Engineering Bernard and Irene Schwartz Center for Biomedical Imaging Department of Biomaterials Department of Chemistry College of Dentistry 2 R Center for Genomics and Systems Biology Center for Computational Biology New York University School of Medicine SUNY Downstate Medical Center Flatiron Institute Department of Radiology |
AuthorAffiliation_xml | – name: School of Medicine – name: Department of Chemistry – name: Tandon School of Engineering – name: Bernard and Irene Schwartz Center for Biomedical Imaging – name: Center for Advanced Imaging Innovation and Research (CAI – name: Flatiron Institute – name: Center for Computational Biology – name: Courant Institute of Mathematical Sciences – name: SUNY Downstate Medical Center – name: Department of Biomedical Engineering – name: 2 – name: Center for Genomics and Systems Biology – name: Simons Foundation – name: Department of Radiology – name: Computer Science Department – name: Department of Chemical and Biomolecular Engineering – name: New York University – name: Department of Biomaterials – name: R – name: College of Dentistry – name: Department of Biomedical Engineering, SUNY Downstate Medical Center, Brooklyn, New York, 11203, USA – name: Center for Advanced Imaging Innovation and Research (CAI 2 R), New York University School of Medicine, New York, New York, 10016, USA – name: Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, 10016, USA – name: Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA – name: Courant Institute of Mathematical Sciences, Computer Science Department, New York University, New York, New York, 10009, USA – name: Department of Chemistry, New York University, New York, New York, 10012, USA – name: Department of Biomaterials, New York University College of Dentistry, New York, New York, 10010, USA – name: Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, 10010, USA – name: Center for Genomics and Systems Biology, New York University, New York, New York, 10003, USA |
Author_xml | – sequence: 1 givenname: Lindsay K surname: Hill fullname: Hill, Lindsay K – sequence: 2 givenname: Dustin surname: Britton fullname: Britton, Dustin – sequence: 3 givenname: Teeba surname: Jihad fullname: Jihad, Teeba – sequence: 4 givenname: Kamia surname: Punia fullname: Punia, Kamia – sequence: 5 givenname: Xuan surname: Xie fullname: Xie, Xuan – sequence: 6 givenname: Erika surname: Delgado-Fukushima fullname: Delgado-Fukushima, Erika – sequence: 7 givenname: Che Fu surname: Liu fullname: Liu, Che Fu – sequence: 8 givenname: Orin surname: Mishkit fullname: Mishkit, Orin – sequence: 9 givenname: Chengliang surname: Liu fullname: Liu, Chengliang – sequence: 10 givenname: Chunhua surname: Hu fullname: Hu, Chunhua – sequence: 11 givenname: Michael surname: Meleties fullname: Meleties, Michael – sequence: 12 givenname: P. Douglas surname: Renfrew fullname: Renfrew, P. Douglas – sequence: 13 givenname: Richard surname: Bonneau fullname: Bonneau, Richard – sequence: 14 givenname: Youssef Z surname: Wadghiri fullname: Wadghiri, Youssef Z – sequence: 15 givenname: Jin Kim surname: Montclare fullname: Montclare, Jin Kim |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37274761$$D View this record in MEDLINE/PubMed https://www.osti.gov/biblio/1868130$$D View this record in Osti.gov |
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CitedBy_id | crossref_primary_10_1016_j_bej_2024_109261 crossref_primary_10_1021_acsbiomaterials_4c00349 crossref_primary_10_3390_jcs7050199 crossref_primary_10_1021_acs_biomac_2c01031 crossref_primary_10_1021_acsanm_3c04357 |
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Snippet | Labeled protein-based biomaterials have become popular for various biomedical applications such as tissue-engineered, therapeutic, and diagnostic scaffolds.... Labeled protein-based biomaterials have become a popular for various biomedical applications such as tissue-engineered, therapeutic, or diagnostic scaffolds.... This protein–iron oxide hybrid biomaterial aims to integrate the drug encapsulating potential of a coiled-coil protein with peptide-driven iron oxide... |
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SubjectTerms | Alkynes Antibodies Binding Biocompatibility Biomedical engineering Biomedical materials Coils Cycloaddition Doxorubicin Encapsulation Glycoproteins Hydrogels Iron oxides Magnetic resonance imaging Medical imaging Nanofibers Nanoparticles Proteins Scaffolds Surgical implants Tissue engineering |
Title | Engineered protein-iron oxide hybrid biomaterial for MRI-traceable drug encapsulation |
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