A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection

• Published in: Science advances Vol. 8; no. 1; p. eabh3827
• Main Authors: Iwata-Yoshikawa, Naoko, Shiwa, Nozomi, Sekizuka, Tsuyoshi, Sano, Kaori, Ainai, Akira, Hemmi, Takuya, Kataoka, Michiyo, Kuroda, Makoto, Hasegawa, Hideki, Suzuki, Tadaki, Nagata, Noriyo
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 07.01.2022
• Subjects: Biomedicine and Life Sciences; Coronavirus; SciAdv r-articles; Virology

Eosinophilic immunopathology was induced by T H 2-shifted immune response and inadequate neutralizing antibody in BALB/c mice. One safety concern during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine development has been the vaccine-associated enhanced disease, which is charact...