Topical Vancomycin Paste Over the Sternal Edge During Cardiac Surgery: Effects of Renal Function and Body Size on Systemic Exposure

• Published in: Clinical therapeutics Vol. 47; no. 2; pp. 135 - 142
• Main Authors: Tsai, Meng-Ta, Hu, Yu-Ning, Roan, Jun-Neng, Kan, Chung-Dann, Wang, Yi-Chen, Luo, Chwan-Yau, Chou, Chen-Hsi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2025; Elsevier Limited
• Subjects: Administration, Topical; Adults; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Body Size; Body Surface Area; Cardiac surgery; Cardiac Surgical Procedures - methods; Cardiovascular disease; Chronic illnesses; Coronary vessels; Creatinine; Diabetes; End-stage renal disease; Enzymes; Female; Glomerular Filtration Rate; Heart surgery; Hemodialysis; Humans; Infections; Internal Medicine; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - physiopathology; Male; Middle Aged; Patients; Pharmacokinetics; Plasma; Postoperative period; Renal function; Sternum; Sternum - surgery; Surgery; Surgical Wound Infection - prevention & control; Systemic exposure; Topical vancomycin; Vancomycin; Vancomycin - administration & dosage; Vancomycin - blood; Vancomycin - pharmacokinetics; Variables; Wound infection; Japan; Systemic exposure; Renal function; Body surface area; Cardiac surgery; Sternum; Topical vancomycin

•Body size and renal status affect plasma exposure after topical sternal vancomycin.•Minimal systemic exposure, even with small body size or impaired renal function.•For hemodialysis patients, accumulation of plasma vancomycin is worth cautioning. Intraoperative topical vancomycin has been widely us...