Topical Vancomycin Paste Over the Sternal Edge During Cardiac Surgery: Effects of Renal Function and Body Size on Systemic Exposure - Tsai, Meng-Ta; Hu, Yu-Ning; Roan, Jun-Neng; Kan, Chung-Dann; Wang, Yi-Chen; Luo, Chwan-Yau; Chou, Chen-Hsi (Clinical therapeutics, 2025)
Keywords: Administration, Topical; Adults; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Body Size; Body Surface Area; Cardiac surgery; Cardiac Surgical Procedures - methods; Cardiovascular disease; Chronic illnesses; Coronary vessels; Creatinine; Diabetes; End-stage renal disease; Enzymes; Female; Glomerular Filtration Rate; Heart surgery; Hemodialysis; Humans; Infections; Internal Medicine; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - physiopathology; Male; Middle Aged; Patients; Pharmacokinetics; Plasma; Postoperative period; Renal function; Sternum; Sternum - surgery; Surgery; Surgical Wound Infection - prevention & control; Systemic exposure; Topical vancomycin; Vancomycin; Vancomycin - administration & dosage; Vancomycin - blood; Vancomycin - pharmacokinetics; Variables; Wound infection; Japan; Systemic exposure; Renal function; Body surface area; Cardiac surgery; Sternum; Topical vancomycin