Vascular Endothelial Growth Factor Expression of Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), and E-selectin through Nuclear Factor-κB Activation in Endothelial Cells

• Published in: The Journal of biological chemistry Vol. 276; no. 10; pp. 7614 - 7620
• Main Authors: Kim, Injune, Moon, Sang-Ok, Hoon Kim, Sung, Jin Kim, Hyung, Soon Koh, Young, Young Koh, Gou
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.03.2001
• Subjects: Androstadienes - pharmacology; Blotting, Western; Cell Adhesion; Cells, Cultured; DNA, Complementary - metabolism; E-selectin; E-Selectin - biosynthesis; Endothelial Growth Factors - biosynthesis; Endothelium, Vascular - metabolism; Enzyme Activation; Enzyme Inhibitors - pharmacology; Flow Cytometry; Humans; intercellular adhesion molecule 1; Intercellular Adhesion Molecule-1 - biosynthesis; Leukocytes - metabolism; Lymphokines - biosynthesis; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors; Models, Biological; NF-kappa B - antagonists & inhibitors; NF-kappa B - metabolism; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase - metabolism; Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors; Protein Kinase C - antagonists & inhibitors; Protein Structure, Tertiary; Protein-Serine-Threonine Kinases - antagonists & inhibitors; Protein-Tyrosine Kinases - antagonists & inhibitors; Recombinant Proteins - metabolism; Ribonucleases - metabolism; RNA, Messenger - metabolism; Signal Transduction; Time Factors; Type C Phospholipases - antagonists & inhibitors; Umbilical Veins - cytology; vascular cell adhesion molecule 1; Vascular Cell Adhesion Molecule-1 - biosynthesis; vascular endothelial growth factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation. Here we examined the mechanisms underlying VEGF-stimulated expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in human umbi...