Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

• Published in: Journal of the American Society of Nephrology Vol. 28; no. 7; pp. 2053 - 2067
• Main Authors: Wang, Ying-Ying, Jiang, Hong, Pan, Jun, Huang, Xiao-Ru, Wang, Yu-Cheng, Huang, Hong-Feng, To, Ka-Fai, Nikolic-Paterson, David J., Lan, Hui-Yao, Chen, Jiang-Hua
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.07.2017
• Subjects: Allografts; Animals; Basic Research; Cell Transdifferentiation; Chronic Disease; Female; Fibrosis - etiology; Humans; Kidney - pathology; Kidney Diseases - etiology; Kidney Transplantation; Macrophages - cytology; Macrophages - physiology; Male; Mice; Mice, Inbred C57BL; Myofibroblasts - cytology; Myofibroblasts - physiology; Postoperative Complications - etiology; macrophage myofibroblast transition; M2 macrophage; Smad3; lineage tracing; interstitial fibrosis; chronic allograft rejection

Interstitial fibrosis is an important contributor to graft loss in chronic renal allograft injury. Inflammatory macrophages are associated with fibrosis in renal allografts, but how these cells contribute to this damaging response is not clearly understood. Here, we investigated the role of macropha...