Stable Isotopic Tracer Phospholipidomics Reveals Contributions of Key Phospholipid Biosynthetic Pathways to Low Hepatocyte Phosphatidylcholine to Phosphatidylethanolamine Ratio Induced by Free Fatty Acids

• Published in: Metabolites Vol. 11; no. 3; p. 188
• Main Authors: Peng, Kang-Yu, Barlow, Christopher K, Kammoun, Helene, Mellett, Natalie A, Weir, Jacquelyn M, Murphy, Andrew J, Febbraio, Mark A, Meikle, Peter J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 22.03.2021; MDPI AG
• Subjects: CDP-choline pathway; CDP-ethanolamine pathway; flux analysis; free fatty acid; lipidomics; steatosis; CDP-choline pathway; flux analysis; phosphatidylethanolamine N-methyl transferase (PEMT) pathway; free fatty acid; CDP-ethanolamine pathway; steatosis; lipidomics

There is a strong association between hepatocyte phospholipid homeostasis and non-alcoholic fatty liver disease (NAFLD). The phosphatidylcholine to phosphatidylethanolamine ratio (PC/PE) often draws special attention as genetic and dietary disruptions to this ratio can provoke steatohepatitis and ot...