Polycomb complexes redundantly maintain epidermal stem cell identity during development

• Published in: Genes & development Vol. 35; no. 5-6; pp. 354 - 366
• Main Authors: Cohen, Idan, Bar, Carmit, Liu, Hequn, Valdes, Victor J., Zhao, Dejian, Galbo, Phillip M., Silva, Jose M., Koseki, Haruhiko, Zheng, Deyou, Ezhkova, Elena
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.03.2021
• Subjects: Animals; Cell Differentiation - genetics; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Epidermal Cells - cytology; Epidermal Cells - metabolism; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Mice; Polycomb Repressive Complex 1 - genetics; Polycomb Repressive Complex 1 - metabolism; Polycomb Repressive Complex 2 - genetics; Polycomb Repressive Complex 2 - metabolism; Polycomb-Group Proteins - genetics; Polycomb-Group Proteins - metabolism; Research Paper; Transcription Factors - genetics; Transcription Factors - metabolism; PRC2; stem cell; PRC1; H2AK119ub; skin; Polycomb; epigenetics; H3K27me3; epidermis

Polycomb repressive complex 1 (PRC1) and PRC2 are critical epigenetic developmental regulators. PRC1 and PRC2 largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3. However, the functional contribution of each complex to...