Senescence and the SASP: many therapeutic avenues

• Published in: Genes & development Vol. 34; no. 23-24; pp. 1565 - 1576
• Main Authors: Birch, Jodie, Gil, Jesús
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.12.2020
• Subjects: Aging - genetics; Aging - pathology; Cellular Senescence - genetics; Disease Susceptibility - therapy; Drug Development; Drug Therapy; Epigenesis, Genetic; Gene Expression Regulation; Humans; Pharmaceutical Preparations - chemistry; Review; Secretory Pathway; Signal Transduction; senescence; therapeutics; disease; inflammation; senolytics; cancer; aging; SASP; senomorphics

Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and li...