Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies

• Published in: Chemical science (Cambridge) Vol. 12; no. 2; pp. 6929 - 6948
• Main Authors: Chen, Jiahui, Gao, Kaifu, Wang, Rui, Wei, Guo-Wei
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 26.05.2021; The Royal Society of Chemistry
• Subjects: Antibodies; Binding; Biophysics; Chemistry; Coils; Conversion; Coronaviruses; COVID-19 vaccines; Enzymes; Extreme values; Free energy; Immune system; Mutation; Proteins; Severe acute respiratory syndrome coronavirus 2; Topology; Two dimensional analysis; Vaccines; Viral diseases; United Kingdom > UK

Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19 pandemic. They, however, are prone to over 5000 mutations on the spike (S) protein uncovered by a Mutation Tracker based on over 200 000 genome isolates. It is imperative to understand how mutations will impact v...