Application of viscometry and solubility parameters in miconazole patches development

• Published in: International journal of pharmaceutics Vol. 190; no. 1; pp. 91 - 101
• Main Authors: Minghetti, P., Cilurzo, F., Casiraghi, A., Montanari, L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 10.11.1999; Elsevier
• Subjects: Adhesiveness; Adhesives; Antifungal Agents - chemistry; Antifungal Agents - pharmacokinetics; Biological and medical sciences; Capillary viscometry; Chemistry, Pharmaceutical; Copolymer compatibility; Drug Compounding - instrumentation; Drug Compounding - methods; Drug Delivery Systems; Drug Stability; Evaluation Studies as Topic; General pharmacology; Kinetics; Medical sciences; Methacrylates - chemistry; Miconazole - chemistry; Miconazole - pharmacokinetics; Models, Theoretical; Patches formulation; Patches preformulation; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Placebos; Solubility; Solubility parameter; Viscosity; Solubility parameter; Copolymer compatibility; Patches formulation; Capillary viscometry; Patches preformulation; Viscosity; Imidazole derivatives; Stability; Pharmaceutical technology; Control release polymer; Solubility; Molecular interaction; Drug carrier; Capillary viscosimeter; Percutaneous route; Antifungal agent; Dosage form; Methacrylate copolymer; Compatibility; Miconazole; Mathematical model; Patch; Bioadhesive system; Release; Physicochemical properties

Nine binary mixtures of seven different methacrylic copolymer systems (Plastoid ® E 35 L (PLE) and Plastoid ® L 50 (PLL); Eudragit ® (Eu) NE, RL, RS, L, S) were tested as components of monolayer patches containing miconazole. Only three mixtures (PLE:EuNE, PLE:EuRL and PLE:EuRS) were suitable for th...