Pharmacokinetics and pharmacodynamics of peptide antibiotics

• Published in: Advanced drug delivery reviews Vol. 183; p. 114171
• Main Authors: Bian, Xingchen, Qu, Xingyi, Zhang, Jing, Nang, Sue C., Bergen, Phillip J., Tony. Zhou, Qi, Chan, Hak-Kim, Feng, Meiqing, Li, Jian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2022
• Subjects: Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Antimicrobial peptide; Antimicrobial resistance; Drug Monitoring; Drug Resistance, Multiple, Bacterial; Humans; Peptides - pharmacology; Pharmacodynamics; Pharmacokinetics; Safety; Therapeutic drug monitoring; PK/PD; CBA; Ile; VAP; fAUC; hVISA; VRE; CAPD; LPS; UTIs; AUC; Therapeutic drug monitoring; MSSA; AMPs; cSSSIs; CSF; MRSA; MDR; Safety; pEtN; TDM; OM; AKI; CVVHDF; PBP; Pharmacodynamics; VRSA; OR; VSSA; Dab; L-Ara4N; CI; MIC; CVVHD; XDR; CMS; VISA; VSE; IQR; EVD; Antibiotics; PAE; MIU; Antimicrobial resistance; Pharmacokinetics; AFC; ELF; Antimicrobial peptide

[Display omitted] •Antimicrobial peptide antibiotics are key therapeutic options for the treatment of multidrug-resistant infections.•Pharmacokinetics/Pharmacodynamics is essential to the rational use of antimicrobials.•Structural modifications of the antimicrobial peptide antibiotics can substantia...