Propofol Dosing Regimens for ICU Sedation Based upon an Integrated Pharmacokinetic– Pharmacodynamic Model - Barr, Juliana; Egan, Talmage D.; Sandoval, Nancy F.; Zomorodi, Katayoun; Cohane, Carol; Gambus, Pedro L.; Shafer, Steven L. (Anesthesiology (Philadelphia), 2001)
Keywords: Adult; Aged; Aged, 80 and over; Algorithms; Biological and medical sciences; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - adverse effects; Hypnotics and Sedatives - pharmacokinetics; Hypnotics. Sedatives; Infusions, Intravenous; Intensive Care Units; Male; Medical sciences; Middle Aged; Models, Biological; Neuropharmacology; Pharmacology. Drug treatments; Propofol - administration & dosage; Propofol - adverse effects; Propofol - pharmacokinetics; Prospective Studies; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Human; Pharmacokinetic pharmacodynamic relationship; Intensive care; Intravenous administration; Hypnotic; Sedation; Dose activity relation; Activity concentration relation; Perfusion; Models; Propofol; Sedative; Pharmacokinetics