Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

• Published in: Journal of the American Society of Nephrology Vol. 29; no. 4; pp. 1238 - 1256
• Main Authors: Luo, Congwei, Zhou, Shan, Zhou, Zhanmei, Liu, Yahong, Yang, Li, Liu, Jiafeng, Zhang, Yunfang, Li, Hongyan, Liu, Youhua, Hou, Fan Fan, Zhou, Lili
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.04.2018
• Subjects: Basic Research; Wnt9a; fibroblasts; tubular cells; renal fibrosis; cell senescence

Cellular senescence is associated with renal disease progression, and accelerated tubular cell senescence promotes the pathogenesis of renal fibrosis. However, the underlying mechanism is unknown. We assessed the potential role of Wnt9a in tubular cell senescence and renal fibrosis. Compared with tu...