Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention

• Published in: International journal of pharmaceutics Vol. 180; no. 2; pp. 185 - 193
• Main Authors: Felt, O., Furrer, P., Mayer, J.M., Plazonnet, B., Buri, P., Gurny, R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.04.1999; Elsevier
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biocompatible Materials - administration & dosage; Biocompatible Materials - adverse effects; Biocompatible Materials - pharmacokinetics; Biological and medical sciences; Chitin - administration & dosage; Chitin - adverse effects; Chitin - analogs & derivatives; Chitin - pharmacokinetics; Chitosan; Cornea - diagnostic imaging; Cornea - drug effects; Cornea - metabolism; Gamma Cameras; Gamma scintigraphy; Gels; General pharmacology; Hydrogen-Ion Concentration; Male; Medical sciences; Microscopy, Confocal; Ocular tolerance; Ophthalmic Solutions; Ophthalmoscopy; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Precorneal retention; Rabbits; Radionuclide Imaging; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - pharmacokinetics; Technetium Tc 99m Pentetate - administration & dosage; Technetium Tc 99m Pentetate - pharmacokinetics; Tobramycin - administration & dosage; Tobramycin - pharmacokinetics; Viscosity; Ocular tolerance; Chitosan; Precorneal retention; Gamma scintigraphy; Ophthalmoscopy; Viscosity; Pharmaceutical technology; Toxicity; Rabbit; Drug carrier; Scintigraphy; Lagomorpha; Retention time; Eye drop; Colloidal gel; Eye; Vertebrata; Antibiotic; Mammalia; Aminoglycoside; Animal; Dosage form; Ophthalmology; Tobramycin; Antibacterial agent; Topical administration

The mucoadhesive polysaccharide chitosan was evaluated as a potential component in ophthalmic gels for enabling increased precorneal drug residence times. This cationic vehicle was expected to slow down drug elimination by the lacrymal flow both by increasing solution viscosity and by interacting wi...