The Effect of Dexmedetomidine on Inflammatory Factors and Clinical Outcomes in Patients With Septic Shock: A Randomized Clinical Trial

• Published in: Clinical therapeutics Vol. 47; no. 1; pp. e9 - e17
• Main Authors: Mokhlesian, Mahdi, Heydari, Fatemeh, Boskabadi, Seyyed Javad, Baradari, Afshin Gholipour, Ajami, Abolghasem, Alizadeh-Navaei, Reza
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025; Elsevier Limited
• Subjects: Aged; Analgesics; Anesthesia; Biomarkers; Biomarkers - blood; Blood pressure; Chronic obstructive pulmonary disease; Clinical outcomes; Clinical trials; Cytokines; Delirium; Dexmedetomidine; Dexmedetomidine - administration & dosage; Dexmedetomidine - pharmacology; Dexmedetomidine - therapeutic use; Female; Guardians; Heart rate; Humans; Hypnotics and Sedatives - therapeutic use; IL-6; Inflammation; Inflammation Mediators - blood; Inflammatory cytokines; Interleukin 1; Interleukin 6; Interleukin-6 - blood; Internal Medicine; Intervention; Male; Midazolam; Midazolam - administration & dosage; Midazolam - therapeutic use; Middle Aged; Morphine; Morphine - administration & dosage; Morphine - therapeutic use; Mortality; Norepinephrine; Norepinephrine - administration & dosage; Norepinephrine - therapeutic use; Patients; Sepsis; Septic shock; Serum levels; Shock, Septic - blood; Shock, Septic - drug therapy; Shock, Septic - physiopathology; Software; TNF-α; Treatment Outcome; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-α; Vital signs; Septic shock; Inflammatory cytokines; TNF-α; IL-6; Dexmedetomidine

•Dexmedetomidine is an α2-adrenoceptor agonist with sedative and anesthetic effects.•There are limited human studies on the effects of dexmedetomidine in septic shock.•In this clinical trial, we investigated the effect of dexmedetomidine on inflammatory factors, SOFA score, vital signs, and norepine...