Intravenous Iron Dosing and Infection Risk in Patients on Hemodialysis: A Prespecified Secondary Analysis of the PIVOTAL Trial

• Published in: Journal of the American Society of Nephrology Vol. 31; no. 5; pp. 1118 - 1127
• Main Authors: Macdougall, Iain C., Bhandari, Sunil, White, Claire, Anker, Stefan D., Farrington, Kenneth, Kalra, Philip A., Mark, Patrick B., McMurray, John J. V., Reid, Chante, Robertson, Michele, Tomson, Charles R.V., Wheeler, David C., Winearls, Christopher G., Ford, Ian
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.05.2020
• Subjects: Aged; Arteriovenous Shunt, Surgical - adverse effects; Cardiovascular Diseases - epidemiology; Catheter-Related Infections - epidemiology; Catheter-Related Infections - etiology; Cause of Death; Clinical Research; Cross Infection - epidemiology; Dose-Response Relationship, Drug; Female; Hospitalization; Humans; Infections - epidemiology; Infections - etiology; Infusions, Intravenous; Iron - administration & dosage; Iron - therapeutic use; Male; Middle Aged; Proportional Hazards Models; Renal Dialysis - adverse effects; Renal Dialysis - instrumentation; Survival Analysis; intravenous iron; hemodialysis; infections; chronic kidney disease; randomized controlled trial

Experimental and observational studies have raised concerns that giving intravenous (IV) iron to patients, such as individuals receiving maintenance hemodialysis, might increase the risk of infections. The Proactive IV Iron Therapy in Haemodialysis Patients (PIVOTAL) trial randomized 2141 patients u...