GSK-3β Controls Osteogenesis through Regulating Runx2 Activity

• Published in: PloS one Vol. 2; no. 9; p. e837
• Main Authors: Kugimiya, Fumitaka, Kawaguchi, Hiroshi, Ohba, Shinsuke, Kawamura, Naohiro, Hirata, Makoto, Chikuda, Hirotaka, Azuma, Yoshiaki, Woodgett, James R, Nakamura, Kozo, Chung, Ung-il
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 05.09.2007
• Subjects: Biocompatibility; Biology; Bone density; Bone dysplasia; Bone growth; Bone marrow; Cbfa-1 protein; Cell Biology/Developmental Molecular Mechanisms; Craniofacial syndromes; Developmental Biology/Cell Differentiation; Diabetes; Fibroblasts; Gene expression; Genetics and Genomics/Animal Genetics; Glycogen; Glycogen synthase kinase 3; Growth factors; Insulin; Integrative medicine; Kinases; Lithium; Lithium chloride; Medicine; Metabolism; Mice; Musculoskeletal system; Oral administration; Osteogenesis; Osteoporosis; Phosphorylation; Proteins; Studies; Transcription; Transcription factors

Despite accumulated knowledge of various signalings regulating bone formation, the molecular network has not been clarified sufficiently to lead to clinical application. Here we show that heterozygous glycogen synthase kinase-3β (GSK-3β)-deficient mice displayed an increased bone formation due to an...