(S)-Equol Is More Effective than (R)-Equol in Inhibiting Osteoclast Formation and Enhancing Osteoclast Apoptosis, and Reduces Estrogen Deficiency–Induced Bone Loss in Mice - Tanaka, Miori; Fujii, Shungo; Inoue, Hirofumi; Takahashi, Nobuyuki; Ishimi, Yoshiko; Uehara, Mariko (The Journal of nutrition, 2022)
Keywords: Animals; Apoptosis; Biological properties; Biomedical materials; Bone Density; Bone Diseases, Metabolic; Bone loss; Bone marrow; Bone mineral density; Bone Resorption - drug therapy; Bone Resorption - prevention & control; Bone turnover; Caspase 3; Caspase 7; Cell differentiation; Daidzein; Enantiomers; Equol - pharmacology; Equol - therapeutic use; equol enantiomers; Estrogen receptors; Estrogens; Estrogens - pharmacology; Female; Fractures; Fragility; Gene expression; In vitro methods and tests; In vivo methods and tests; Kidneys; Metabolism; Metabolites; Mice; Mice, Inbred Strains; Osteoblastogenesis; Osteoblasts; Osteoclastogenesis; Osteoclasts; osteoporosis; ovariectomized mice; Ovariectomy; Rodents; Tibia; S-eq; DC-STAMP; RANKL; JNK; Ctsk; NFATc1; TRAP; 1α,25-(OH)2D3; AP-1; OVX; bone mineral density; PPAR; BMD; BMC; CCK-8; osteoclastogenesis; R-eq; OC-STAMP; SERM; osteoporosis; MAPK; ER; OSCAR; ovariectomized mice; equol enantiomers; ERK